Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/85171
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Gonçalves, Anabela | por |
dc.contributor.author | Fernandes, Mário | por |
dc.contributor.author | Lima, Margarida | por |
dc.contributor.author | Gomes, João Pedro | por |
dc.contributor.author | Silva, Filipa | por |
dc.contributor.author | Castro, Sara | por |
dc.contributor.author | Sampaio, Filipa | por |
dc.contributor.author | Gomes, Andreia C | por |
dc.date.accessioned | 2023-06-23T10:42:08Z | - |
dc.date.available | 2023-06-23T10:42:08Z | - |
dc.date.issued | 2023-02-01 | - |
dc.identifier.citation | Gonçalves, A.; Fernandes, M.; Lima, M.; Gomes, J.P.; Silva, F.; Castro, S.; Sampaio, F.; Gomes, A.C. Nanotechnology to the Rescue: Therapeutic Strategies Based on Brown Algae for Neurodegenerative Diseases. Appl. Sci. 2023, 13, 1883. https://doi.org/10.3390/app13031883 | por |
dc.identifier.uri | https://hdl.handle.net/1822/85171 | - |
dc.description.abstract | In the last decades, marine macroalgae have drawn attention mainly because of their bioactive constituents. Most brown algae are distributed over coastal areas of the Atlantic Ocean, Mediterranean Sea, Aegean Sea and Black Sea, and their composition varies with endogenous and exogenous factors. Phlorotannins, fatty acids, sterols and carbohydrates are some of the compounds responsible for biological activities related to cytotoxic, antiviral, antifungal, antibacterial, antidiabetic, antioxidant and anti-inflammatory potential. In this review we seek to highlight some of the compounds responsible for these last two biological activities, which have enormous importance for the management of neurodegenerative diseases, such as Alzheimer and Parkinson’s, with neuroinflammation and oxidative stress as hallmarks. However, one of the major problems associated with treating these diseases is the highly selective blood-brain-barrier, which can be overcome with nanocarriers used as delivery systems. Weighing the risks, benefits and toxicity of the used nanoparticles is nevertheless important. We also discuss zebrafish as an upcoming adequate biological model for in vivo screening of risks and benefits of such treatment strategies. This review aims to enable researchers working in the exploitation of these macroalgae and in the use of nanocarriers to potentiate the controlled delivery of bioactive compounds. | por |
dc.description.sponsorship | This work was supported by the project ATLANTIDA (NORTE-01-0145-FEDER-000040), funded by the Norte Portugal Regional Operational Programme (NORTE 2020) under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and the strategic programme UID/BIA/04050/2020 funded by National funds through the Fundação para a Ciência e Tecnologia I.P. Mário Fernandes (SFRH/BD/147819/2019) and Anabela Gonçalves (SFRH/BD/146807/2019) hold scholarships from Fundação para a Ciência e a Tecnologia I.P. | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | por |
dc.relation | UID/BIA/04050/2020 | por |
dc.relation | SFRH/BD/147819/2019 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F146807%2F2019/PT | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | Brown algae | por |
dc.subject | Antioxidant activity | por |
dc.subject | Anti-inflammatory activity | por |
dc.subject | Neurodegenerative diseases | por |
dc.subject | Nanoparticles | por |
dc.subject | Zebrafish model | por |
dc.title | Nanotechnology to the rescue: therapeutic strategies based on brown algae for neurodegenerative diseases | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2076-3417/13/3/1883 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 20 | por |
oaire.citationIssue | 3 | por |
oaire.citationVolume | 13 | por |
dc.date.updated | 2023-02-10T14:28:49Z | - |
dc.identifier.eissn | 2076-3417 | - |
dc.identifier.doi | 10.3390/app13031883 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Applied Sciences | por |
oaire.version | VoR | por |
dc.identifier.articlenumber | 1883 | por |
Aparece nas coleções: | CBMA - Artigos/Papers DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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applsci-13-01883.pdf | 6,27 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons