Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/85094
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Campo DC | Valor | Idioma |
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dc.contributor.author | Vinayakumar, K. B. | por |
dc.contributor.author | Silva, Maria Daniela | por |
dc.contributor.author | Martins, Artur | por |
dc.contributor.author | Mundy, Stephen | por |
dc.contributor.author | González-Losada, Pedro | por |
dc.contributor.author | Sillankorva, Sanna M. | por |
dc.date.accessioned | 2023-06-20T08:40:40Z | - |
dc.date.available | 2023-06-20T08:40:40Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.citation | Vinayakumar, K. B.; Silva, Maria Daniela; Martins, Artur; Mundy, Stephen; González-Losada, Pedro; Sillankorva, Sanna M., Levofloxacin-loaded microneedles produced using 3D-printed molds for Klebsiella pneumoniae biofilm control. Advanced Therapeutics, 6(6), 2200320, 2023 | por |
dc.identifier.issn | 2366-3987 | por |
dc.identifier.uri | https://hdl.handle.net/1822/85094 | - |
dc.description.abstract | Additive manufacturing advancements contribute considerably to several fields, and its use in the medical field is gaining attention due to its easily customizable option (patient-specific), low cost, and fast turnout time in developing drug delivery and diagnostic tools. Here, wereport the fabrication of a microneedle (MN) platform using a stereolithography 3D printer, varying the 3D printing angle and aspect ratio (2:1, 3:1, 4:1). The optimal printing angle was30, resulting in needle tip and base diameters of 50 µm and 330 µm, and heights of 550/850/1180 µm. Polyvinyl alcohol (PVA) MNs produced with varying levofloxacin concentrations showed variability of 4% in tip and 3% base diameters and 15% in height compared to the 3D-printed MNs. Geometry B wasused to produce levofloxacin-loaded PVA MNs and tested against Klebsiella pneumoniae colony biofilms. Levofloxacin wasreleased gradually, as assessed by spectrofluorimetry. The MIC of levofloxacin against the K. pneumoniae clinical isolate was4 µg/mL, but this concentration wasinsufficient to cause any effect on K. pneumoniae biofilms. Only concentrations 32 µg/mL werestatistically different compared to the unloaded MNs. 3D printing is an attractive solution to produce molds for fabricating biopolymeric MNs for topical drug delivery. | por |
dc.description.sponsorship | S.S. acknowledges funding by FCT through the individual scientific employment program contract (2020.03171.CEECIND). The radius was corrected to diameter on June 12, 2023. | por |
dc.language.iso | eng | por |
dc.publisher | Wiley | por |
dc.relation | 2020.03171.CEECIND | por |
dc.rights | openAccess | por |
dc.subject | 3D printing | por |
dc.subject | biofilms | por |
dc.subject | Klebsiella pneumoniae | por |
dc.subject | levofloxacin | por |
dc.subject | microneedles | por |
dc.subject | polyvinyl alcohol | por |
dc.title | Levofloxacin-loaded microneedles produced using 3D-printed molds for Klebsiella pneumoniae biofilm control | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/adtp.202200320 | por |
dc.comments | CEB56159 | por |
oaire.citationStartPage | 2200320 | por |
oaire.citationIssue | 6 | por |
oaire.citationVolume | 6 | por |
dc.date.updated | 2023-06-17T09:08:07Z | - |
dc.identifier.doi | 10.1002/adtp.202200320 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Advanced Therapeutics | por |
oaire.version | AM | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_56159_1.pdf | 2,94 MB | Adobe PDF | Ver/Abrir |