Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/83957
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Ecevit, Kardelen | por |
dc.contributor.author | Barros, Alexandre A. | por |
dc.contributor.author | Silva, Joana M. | por |
dc.contributor.author | Reis, R. L. | por |
dc.date.accessioned | 2023-04-14T13:46:24Z | - |
dc.date.available | 2023-04-14T13:46:24Z | - |
dc.date.issued | 2022-11-02 | - |
dc.identifier.citation | Ecevit, K.; Barros, A.A.; Silva, J.M.; Reis, R.L. Preventing Microbial Infections with Natural Phenolic Compounds. Future Pharmacol. 2022, 2, 460-498. https://doi.org/10.3390/futurepharmacol2040030 | por |
dc.identifier.uri | https://hdl.handle.net/1822/83957 | - |
dc.description.abstract | The struggle between humans and pathogens has taken and is continuing to take countless lives every year. As the misusage of conventional antibiotics increases, the complexity associated with the resistance mechanisms of pathogens has been evolving into gradually more clever mechanisms, diminishing the effectiveness of antibiotics. Hence, there is a growing interest in discovering novel and reliable therapeutics able to struggle with the infection, circumvent the resistance and defend the natural microbiome. In this regard, nature-derived phenolic compounds are gaining considerable attention due to their potential safety and therapeutic effect. Phenolic compounds comprise numerous and widely distributed groups with different biological activities attributed mainly to their structure. Investigations have revealed that phenolic compounds from natural sources exhibit potent antimicrobial activity against various clinically relevant pathogens associated with microbial infection and sensitize multi-drug resistance strains to bactericidal or bacteriostatic antibiotics. This review outlines the current knowledge about the antimicrobial activity of phenolic compounds from various natural sources, with a particular focus on the structure-activity relationship and mechanisms of actions of each class of natural phenolic compounds, including simple phenols, phenolic acids, coumarin, flavonoids, tannins, stilbenes, lignans, quinones, and curcuminoids. | por |
dc.description.sponsorship | The authors acknowledge the financial support by the Portuguese Foundation for Science and Technology (FCT) through the doctoral grant and junior research contract with the reference number PD/BD/150521/2019 (K.E.) and CEECIND/01026/2018 (J.M.S.), respectively. | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/PD%2FBD%2F150521%2F2019/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F01026%2F2018%2FCP1581%2FCT0016/PT | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | Microbiota | por |
dc.subject | Multidrug resistance | por |
dc.subject | Alternative therapeutics | por |
dc.subject | Natural compounds | por |
dc.subject | Phenolic compounds | por |
dc.subject | Structure-function | por |
dc.title | Preventing microbial infections with natural phenolic compounds | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2673-9879/2/4/30 | por |
oaire.citationStartPage | 460 | por |
oaire.citationEndPage | 498 | por |
oaire.citationIssue | 4 | por |
oaire.citationVolume | 2 | por |
dc.date.updated | 2022-12-22T14:35:23Z | - |
dc.identifier.eissn | 2673-9879 | - |
dc.identifier.doi | 10.3390/futurepharmacol2040030 | por |
sdum.journal | Future Pharmacology | por |
oaire.version | VoR | por |
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Ficheiro | Descrição | Tamanho | Formato | |
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futurepharmacol-02-00030-v3.pdf | 3,46 MB | Adobe PDF | Ver/Abrir |
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