Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/81729
Título: | Biodegradable polymer-based microfluidic membranes for sustainable point-of-care devices |
Autor(es): | Brito-Pereira, Ricardo Ribeiro, Clarisse Marta Oliveira Lanceros-Méndez, S. Cardoso, Vanessa Fernandes |
Palavras-chave: | Poly(lactide-co-glycolide acid) Biodegradable Sustainability Portable analytical devices, Point-of-care Microfluidic |
Data: | 15-Out-2022 |
Editora: | Elsevier 1 |
Revista: | Chemical Engineering Journal |
Resumo(s): | Microfluidic paper-based analytical devices (µPADs) have gained substantial attention as portable analytical devices in various (bio)technological fields, for being affordable, user-friendly, portable, energy efficient and for allowing multiplexed analysis. Although significant progress has been achieved, there is still need for improvement in terms of performance and sustainability. In this work, a biodegradable aliphatic polyester poly(D,L-lactide-co-glycolide acid) lactide:glycolide 50:50 (PDLG), is used to produce pore- and fibre-based membranes, as alternative to conventional paper substrates. Two fabrication methods are used, with potential for industrial scale-up. The processed hydrophobic membranes are post-treated with oxygen plasma to turn them hydrophilic, allowing capillary flows. The physicochemical characterization demonstrates the suitability of the plasma-treated PDLG membranes as microfluidic substrates based on their tailorable morphologies and capillary flow rate from 36.2 ± 4.2 to 84.1 ± 5.2 mm·min−1, excellent mechanical properties and biocompatibility. Further, the membranes maintain their properties for at least 6 months when kept in vacuum and degrade quickly after their use (reaching values higher than 90% after 6 weeks when wet). Finally, portable analytical platforms suitable for the colorimetric quantification of glucose are demonstrated. These results are of great importance for the design and manufacture of a new generation of sustainable portable analytical devices, compatible with circular economy paradigms, and a step forward to cross the challenging academia to industry barrier for their commercialization and widespread adoption. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/81729 |
DOI: | 10.1016/j.cej.2022.137639 |
ISSN: | 1385-8947 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
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Este trabalho está licenciado sob uma Licença Creative Commons