Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/81092
Título: | An insight on the biomedical potential of portuguese propolis from Gerês |
Autor(es): | Araújo, Carina Oliveira, Rafaela Dias Pinto-Ribeiro, Filipa Almeida Aguiar, Cristina |
Palavras-chave: | Portuguese propolis Osteoarthritis Chemical composition Antioxidant activity Anti-inflammatory activity |
Data: | 29-Out-2022 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | Foods |
Citação: | Araújo, C.; Oliveira, R.D.; Pinto-Ribeiro, F.; Almeida-Aguiar, C. An Insight on the Biomedical Potential of Portuguese Propolis from Gerês. Foods 2022, 11, 3431. https://doi.org/10.3390/foods11213431 |
Resumo(s): | Osteoarthritis (OA), a progressive degenerative disease of weight-bearing joints, is the second leading cause of disability in the world. Despite all the advances and research over the last years, none of the proposed strategies has been effective in generating functional and long-lasting tissue. Due to the high prevalence of OA and the urgent need for an effective and successful treatment, interest in natural products as anti-inflammatory agents, such as propolis and its components, has emerged. In this work, we estimate the biomedical potential of Portuguese propolis, evaluating the in vitro antioxidant and anti-inflammatory effects of single hydroalcoholic extracts prepared with propolis from Gerês sampled over a five-year period (2011–2015) (G.EE<sub>70</sub> and G.EE<sub>35</sub>). The in vivo and in vitro anti-inflammatory potential of the hydroalcoholic extract of mixtures of the same samples (mG.EE<sub>70</sub> and mG.EE<sub>35</sub>) was evaluated for the first time too. DPPH• radical scavenging and superoxide anion scavenging assays showed the strong antioxidant potential of both hydroalcoholic extracts, either prepared from single propolis samples or from the mixtures of the same samples. Results also revealed an anti-inflammatory effect of mG.EE<sub>35,</sub> both in vitro by inhibiting BSA denaturation and in vivo in the OA-induced model by improving mechanical hyperalgesia as well as the gait pattern parameters. Results further support the use of propolis blends as a better and more efficient approach to take full advantage of the bioactive potential of propolis. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/81092 |
DOI: | 10.3390/foods11213431 |
e-ISSN: | 2304-8158 |
Versão da editora: | https://www.mdpi.com/2304-8158/11/21/3431 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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foods-11-03431-v2.pdf | 3,97 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons