Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/80788
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Almeida-Nunes, Diana Luísa | por |
dc.contributor.author | Frias, Ana Isabel Mendes | por |
dc.contributor.author | Silvestre, Ricardo Jorge Leal | por |
dc.contributor.author | Dinis-Oliveira, Ricardo Jorge | por |
dc.contributor.author | Ricardo, Sara | por |
dc.date.accessioned | 2022-11-22T16:29:59Z | - |
dc.date.available | 2022-11-22T16:29:59Z | - |
dc.date.issued | 2022-09-14 | - |
dc.identifier.citation | Almeida-Nunes, D.L.; Mendes-Frias, A.; Silvestre, R.; Dinis-Oliveira, R.J.; Ricardo, S. Immune Tumor Microenvironment in Ovarian Cancer Ascites. Int. J. Mol. Sci. 2022, 23, 10692. https://doi.org/ 10.3390/ijms231810692 | por |
dc.identifier.issn | 1661-6596 | por |
dc.identifier.uri | https://hdl.handle.net/1822/80788 | - |
dc.description.abstract | Ovarian cancer (OC) has a specific type of metastasis, via transcoelomic, and most of the patients are diagnosed at advanced stages with multiple tumors spread within the peritoneal cavity. The role of Malignant Ascites (MA) is to serve as a transporter of tumor cells from the primary location to the peritoneal wall or to the surface of the peritoneal organs. MA comprise cellular components with tumor and non-tumor cells and acellular components, creating a unique microenvironment capable of modifying the tumor behavior. These microenvironment factors influence tumor cell proliferation, progression, chemoresistance, and immune evasion, suggesting that MA play an active role in OC progression. Tumor cells induce a complex immune suppression that neutralizes antitumor immunity, leading to disease progression and treatment failure, provoking a tumor-promoting environment. In this review, we will focus on the High-Grade Serous Carcinoma (HGSC) microenvironment with special attention to the tumor microenvironment immunology. | por |
dc.description.sponsorship | This work was supported by Fundacão para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior and European Union through a PhD fellowship (2021.05081.BD) cosponsored by Fundo Social Europeu (FSE) through Programa Operacional Regional Norte (Norte 2020). | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | Ovarian cancer | por |
dc.subject | Malignant ascites | por |
dc.subject | Tumor microenvironment | por |
dc.subject | Immune cells | por |
dc.subject | Cytokines | por |
dc.subject | High-grade serous carcinoma | por |
dc.title | Immune tumor microenvironment in ovarian cancer ascites | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/23/18/10692 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 23 | por |
oaire.citationIssue | 18 | por |
oaire.citationVolume | 23 | por |
dc.date.updated | 2022-09-22T12:03:13Z | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.doi | 10.3390/ijms231810692 | por |
dc.identifier.pmid | 36142615 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | International Journal of Molecular Sciences | por |
oaire.version | VoR | por |
dc.identifier.articlenumber | 10692 | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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ijms-23-10692.pdf | 1,87 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons