Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/79798
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Campo DC | Valor | Idioma |
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dc.contributor.author | Teixeira, Cláudia | por |
dc.contributor.author | Pereira, Renato B. | por |
dc.contributor.author | Pinto, Nuno F. S. | por |
dc.contributor.author | Coelho, Catarina M. M. | por |
dc.contributor.author | Fernandes, Maria José G. | por |
dc.contributor.author | Fortes, A. Gil | por |
dc.contributor.author | Gonçalves, M. Sameiro T. | por |
dc.contributor.author | Pereira, David M. | por |
dc.date.accessioned | 2022-09-29T09:52:08Z | - |
dc.date.available | 2022-09-29T09:52:08Z | - |
dc.date.issued | 2022-03-29 | - |
dc.identifier.citation | Teixeira, C.; Pereira, R.B.; Pinto, N.F.S.; Coelho, C.M.M.; Fernandes, M.J.G.; Fortes, A.G.; Gonçalves, M.S.T.; Pereira, D.M. Eugenol β-Amino/β-Alkoxy Alcohols with Selective Anticancer Activity. Int. J. Mol. Sci. 2022, 23, 3759. https://doi.org/10.3390/ijms23073759 | por |
dc.identifier.issn | 1661-6596 | por |
dc.identifier.uri | https://hdl.handle.net/1822/79798 | - |
dc.description.abstract | Eugenol, 4-allyl-2-methoxyphenol, is the main constituent of clove essential oil and has demonstrated relevant biological activity, namely anticancer activity. Aiming to increase this activity, we synthesized a series of eugenol β-amino alcohol and β-alkoxy alcohol derivatives, which were then tested against two human cancer cell lines, namely gastric adenocarcinoma cells (AGS) and lung adenocarcinoma cells (A549). An initial screening was performed to identify the most cytotoxic compounds. The results demonstrated that three β-amino alcohol derivatives had anticancer activity that justified subsequent studies, having been shown to trigger apoptosis. Importantly, the most potent molecules displayed no appreciable toxicity towards human noncancer cells. Structure-activity relationships show that changes in eugenol structure led to enhanced cytotoxic activity and can contribute to the future design of more potent and selective drugs. | por |
dc.description.sponsorship | This research was funded by FCT under project PTDC/ASP-AGR/30154/2017 (PO-CI-01-0145- FEDER-030154) of COMPETE 2020, co-financed by FEDER and EU. FCT-Portugal and FEDERCOMPETE/ QREN-EU also gave financial support to the research centres CQ/UM (UIDB/00686/2020) and REQUIMTE (UIDB/50006/2020). The NMR spectrometer Bruker Avance III 400 (part of the National NMR Network) was financed by FCT and FEDER. Renato B. Pereira acknowledges PRIMA Foundation (H2020- PRIMA 2018—Section 2, Project MILKQUA) and FCT (PTDC/QUI-QFI/2870/2020) for the funding. | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | por |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FASP-AGR%2F30154%2F2017/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00686%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-QFI%2F2870%2F2020/PT | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | Eugenol | por |
dc.subject | β-amino alcohols | por |
dc.subject | β-alkoxy alcohols | por |
dc.subject | Cytotoxicity | por |
dc.subject | Apoptosis | por |
dc.subject | Anticancer | por |
dc.subject | beta-amino alcohols | por |
dc.subject | beta-alkoxy alcohols | por |
dc.title | Eugenol β-amino/β-alkoxy alcohols with selective anticancer activity | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/23/7/3759 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 15 | por |
oaire.citationIssue | 7 | por |
oaire.citationVolume | 23 | por |
dc.date.updated | 2022-04-11T13:59:19Z | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.doi | 10.3390/ijms23073759 | por |
dc.identifier.pmid | 35409123 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | International Journal of Molecular Sciences | por |
oaire.version | VoR | por |
dc.identifier.articlenumber | 3759 | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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ijms-23-03759.pdf | 14,36 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons