Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/79461
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Lopes, Fábio A. C. | por |
dc.contributor.author | Fernandes, André V. F. | por |
dc.contributor.author | Rodrigues, Juliana M. | por |
dc.contributor.author | Queiroz, Maria João R. P. | por |
dc.contributor.author | Almeida, B. G. | por |
dc.contributor.author | Pires, Ana | por |
dc.contributor.author | Pereira, André M. | por |
dc.contributor.author | Araújo, J. P | por |
dc.contributor.author | Castanheira, Elisabete M. S. | por |
dc.contributor.author | Rodrigues, Ana Rita Oliveira | por |
dc.contributor.author | Coutinho, Paulo J. G. | por |
dc.date.accessioned | 2022-09-07T17:14:28Z | - |
dc.date.available | 2022-09-07T17:14:28Z | - |
dc.date.issued | 2022-06-29 | - |
dc.identifier.citation | Lopes, F.A.C.; Fernandes, A.V.F.; Rodrigues, J.M.; Queiroz, M.-J.R.P.; Almeida, B.G.; Pires, A.; Pereira, A.M.; Araújo, J.P.; Castanheira, E.M.S.; Rodrigues, A.R.O.; Coutinho, P.J.G. Magnetoliposomes Containing Multicore Nanoparticles and a New Antitumor Thienopyridine Compound with Potential Application in Chemo/Thermotherapy. Biomedicines 2022, 10, 1547. https://doi.org/10.3390/biomedicines10071547 | por |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.uri | https://hdl.handle.net/1822/79461 | - |
dc.description.abstract | Multicore magnetic nanoparticles of manganese ferrite were prepared using carboxymethyl dextran as an agglutinating compound or by an innovative method using melamine as a cross-coupling agent. The nanoparticles prepared using melamine exhibited a flower-shape structure, a saturation magnetization of 6.16 emu/g and good capabilities for magnetic hyperthermia, with a specific absorption rate (SAR) of 0.14 W/g. Magnetoliposome-like structures containing the multicore nanoparticles were prepared, and their bilayer structure was confirmed by FRET (Förster Resonance Energy Transfer) assays. The nanosystems exhibited sizes in the range of 250–400 nm and a low polydispersity index. A new antitumor thienopyridine derivative, 7-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]thieno[3,2-b]pyridine, active against HeLa (cervical carcinoma), MCF-7 (breast adenocarcinoma), NCI-H460 (non-small-cell lung carcino-ma) and HepG2 (hepatocellular carcinoma) cell lines, was loaded in these nanocarriers, obtaining a high encapsulation efficiency of 98% ± 2.6%. The results indicate that the new magnetoliposomes can be suitable for dual cancer therapy (combined magnetic hyperthermia and chemotherapy). | por |
dc.description.sponsorship | This research was funded by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding of CF-UM-UP (UIDB/04650/2020) and through the research project PTDC/QUI-QFI/28020/2017 (POCI-01-0145-FEDER-028020), financed by the European Fund of Regional Development (FEDER), COMPETE2020, and Portugal2020. J.M.R. acknowledges FCT, ESF (European Social Fund—North Portugal Regional Operational Program) and HCOP (Human Capital Operational Program) for a PhD grant (SFRH/BD/115844/2016). | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04650%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FQUI-QFI%2F28020%2F2017/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F115844%2F2016/PT | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | multicore magnetic nanoparticles | por |
dc.subject | magnetoliposomes | por |
dc.subject | magnetic hyperthermia | por |
dc.subject | antitumor thienopyridine derivative | por |
dc.subject | chemotherapy | por |
dc.title | Magnetoliposomes containing multicore nanoparticles and a new antitumor thienopyridine compound with potential application in chemo/thermotherapy | eng |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2227-9059/10/7/1547 | por |
oaire.citationIssue | 7 | por |
oaire.citationVolume | 10 | por |
dc.identifier.doi | 10.3390/biomedicines10071547 | por |
dc.subject.fos | Engenharia e Tecnologia::Nanotecnologia | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Biomedicines | por |
oaire.version | VoR | por |
dc.identifier.articlenumber | 1547 | por |
dc.subject.ods | Saúde de qualidade | por |
Aparece nas coleções: | PHYSICS OF QUANTUM MATERIALS AND BIONANOSTRUCTURES (2018 - ...) CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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biomedicines-10-01547.pdf | article | 3,45 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons