Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/78140
Título: | Discrimination of idiopathic Parkinson's disease and vascular parkinsonism based on gait time series and the levodopa effect |
Autor(es): | Fernandes, Carlos Ferreira, Flora Lopes, Rui L Bicho, Estela Erlhagen, Wolfram Sousa, Nuno Gago, Miguel F |
Palavras-chave: | Stride time series Multiple regression models Convolutional neural networks diopathic Parkinson’s disease gate Vascular parkinsonism lovadopa Idiopathic  Parkinsons diease  Idiopathic Parkinson's disease |
Data: | 11-Mai-2021 |
Editora: | Elsevier 1 |
Revista: | Journal of Biomechanics |
Citação: | Fernandes, C., Ferreira, F., Lopes, R. L., Bicho, E., Erlhagen, W., Sousa, N., & Gago, M. F. (2021, August). Discrimination of idiopathic Parkinson’s disease and vascular parkinsonism based on gait time series and the levodopa effect. Journal of Biomechanics. Elsevier BV. http://doi.org/10.1016/j.jbiomech.2020.110214 |
Resumo(s): | Idiopathic Parkinson's disease (IPD) and vascular parkinsonism (VaP) present highly overlapping phenotypes, making it challenging to distinguish between these two parkinsonian syndromes. Recent evidence suggests that gait assessment and response to levodopa medication may assist in the objective evaluation of clinical differences. In this paper, we propose a new approach for gait pattern differentiation that uses convolutional neural networks (CNNs) based on gait time series with and without the influence of levodopa medication. Wearable sensors positioned on both feet were used to acquire gait data from 14 VaP patients, 15 IPD patients, and 34 healthy subjects. An individual's gait features are affected by physical characteristics, including age, height, weight, sex, and walking speed or stride length. Therefore, to reduce bias due to intersubject variations, a multiple regression normalization approach was used to obtain gait data. Recursive feature elimination using the linear support vector machine, lasso, and random forest were applied to infer the optimal feature subset that led to the best results. CNNs were implemented by means of various hyperparameters and feature subsets. The best CNN classifiers achieved accuracies of 79.33%±6.46, 82.33%±10.62, and 86.00%±7.12 without (off state), with (on state), and with the simultaneous consideration of the effect of levodopa medication (off/on state), respectively. The response to levodopa medication improved classification performance. Based on gait time series and response to medication, the proposed approach differentiates between IPD and VaP gait patterns and reveals a high accuracy rate, which might prove useful when distinguishing other diseases related to movement disorders. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/78140 |
DOI: | 10.1016/j.jbiomech.2020.110214 |
ISSN: | 0021-9290 |
Versão da editora: | https://doi.org/10.1016/j.jbiomech.2020.110214 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CAlg - Artigos em revistas internacionais / Papers in international journals CMAT - Artigos em revistas com arbitragem / Papers in peer review journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Biomechanics_1-s2.0-S0021929020306382-main.pdf | paper | 1,06 MB | Adobe PDF | Ver/Abrir |