Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/76990
Título: | Heterologous production of Chondroitin |
Autor(es): | Couto, Márcia R. Rodrigues, Joana Lúcia Lima Correia Rodrigues, L. R. |
Palavras-chave: | Chondroitin Glycosaminoglycans Biosynthetic pathway Metabolic engineering Microbial fermentation Heterologous production |
Data: | Mar-2022 |
Editora: | Elsevier B.V. |
Revista: | Biotechnology Reports |
Citação: | Couto, Márcia R.; Rodrigues, Joana L.; Rodrigues, Lígia R., Heterologous production of Chondroitin. Biotechnology Reports, 33(e00710), 2022 |
Resumo(s): | Chondroitin sulfate (CS) is a glycosaminoglycan with a broad range of applications being a popular dietary supplement for osteoarthritis. Usually, CS is extracted from animal sources. However, the known risks of animal products use have been driving the search for alternative methods and sources to obtain this compound. Several pathogenic bacteria naturally produce chondroitin-like polysaccharides through well-known pathways and, therefore, have been the basis for numerous studies that aim to produce chondroitin using non-pathogenic hosts. However, the yields obtained are not enough to meet the high demand for this glycosaminoglycan. Metabolic engineering strategies have been used to construct improved heterologous hosts. The identification of metabolic bottlenecks and regulation points, and the screening for efficient enzymes are key points for constructing microbial cell factories with improved chondroitin yields to achieve industrial CS production. The recent advances on enzymatic and microbial strategies to produce non-animal chondroitin are herein reviewed. Challenges and prospects for future research are also discussed. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/76990 |
DOI: | 10.1016/j.btre.2022.e00710 |
ISSN: | 2215-017X |
Versão da editora: | https://www.journals.elsevier.com/biotechnology-reports |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_55288_1.pdf | 2,23 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons