Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/76476
Título: | Developmental pathways underlying lung development and congenital lung disorders |
Autor(es): | Caldeira, Inês Silva, Hugo Miguel Fernandes Costa, Daniela Machado Correia-Pinto, Jorge Moura, Rute S. |
Palavras-chave: | Congenital pulmonary airway malformation (CPAM) Bronchopulmonary sequestration Bronchogenic cysts Congenital diaphragmatic hernia (CDH) Congenital malformations |
Data: | 2-Nov-2021 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | Cells |
Citação: | Caldeira, I.; Fernandes-Silva, H.; Machado-Costa, D.; Correia-Pinto, J.; Moura, R.S. Developmental Pathways Underlying Lung Development and Congenital Lung Disorders. Cells 2021, 10, 2987. https://doi.org/10.3390/cells10112987 |
Resumo(s): | Lung organogenesis is a highly coordinated process governed by a network of conserved signaling pathways that ultimately control patterning, growth, and differentiation. This rigorously regulated developmental process culminates with the formation of a fully functional organ. Conversely, failure to correctly regulate this intricate series of events results in severe abnormalities that may compromise postnatal survival or affect/disrupt lung function through early life and adulthood. Conditions like congenital pulmonary airway malformation, bronchopulmonary sequestration, bronchogenic cysts, and congenital diaphragmatic hernia display unique forms of lung abnormalities. The etiology of these disorders is not yet completely understood; however, specific developmental pathways have already been reported as deregulated. In this sense, this review focuses on the molecular mechanisms that contribute to normal/abnormal lung growth and development and their impact on postnatal survival. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/76476 |
DOI: | 10.3390/cells10112987 |
ISSN: | 2073-4409 |
Versão da editora: | https://www.mdpi.com/2073-4409/10/11/2987 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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cells-10-02987-v2.pdf | 712,7 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons