Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/74409
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Cátia S. Pereira | por |
dc.contributor.author | Rodrigues, L. R. | por |
dc.contributor.author | Côrte-Real, Manuela | por |
dc.date.accessioned | 2021-10-18T15:35:19Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Cátia S. Pereira; Rodrigues, Lígia R.; Côrte-Real, Manuela, Emerging insights on the role of V-ATPase in human diseases: Therapeutic challenges and opportunities. Medicinal Research Reviews, 2021. | por |
dc.identifier.issn | 0198-6325 | por |
dc.identifier.uri | https://hdl.handle.net/1822/74409 | - |
dc.description.abstract | The control of the intracellular pH is vital for the survival of all organisms. Membrane transporters, both at the plasma and intracellular membranes, are key players in maintaining a finely tuned pH balance between intra- and extracellular spaces, and therefore in cellular homeostasis. V-ATPase is a housekeeping ATP-driven proton pump highly conserved among prokaryotes and eukaryotes. This proton pump, which exhibits a complex multisubunit structure based on cell type-specific isoforms, is essential for pH regulation and for a multitude of ubiquitous and specialized functions. Thus, it is not surprising that V-ATPase aberrant overexpression, mislocalization, and mutations in V-ATPase subunit-encoding genes have been associated with several human diseases. However, the ubiquitous expression of this transporter and the high toxicity driven by its off-target inhibition, renders V-ATPase-directed therapies very challenging and increases the need for selective strategies. Here we review emerging evidence linking V-ATPase and both inherited and acquired human diseases, explore the therapeutic challenges and opportunities envisaged from recent data, and advance future research avenues. We highlight the importance of V-ATPases with unique subunit isoform molecular signatures and disease-associated isoforms to design selective V-ATPase-directed therapies. We also discuss the rational design of drug development pipelines and cutting-edge methodological approaches toward V-ATPase-centered drug discovery. Diseases like cancer, osteoporosis, and even fungal infections can benefit from V-ATPase-directed therapies. | por |
dc.description.sponsorship | European Regional Development Fund, Grant/Award Number: BioTecNorte operation (NORTE‐01‐0145‐FEDER‐000004); Fundação para a Ciência e a Tecnologia, Grant/Award Numbers: PhD fellowship (PD/BD/128032/2016), Strategic funding of UIDB/04469/2020 unit and of “Contrato‐Programa” UIDB/04050/2020 | por |
dc.language.iso | eng | por |
dc.publisher | Wiley-Blackwell | por |
dc.relation | PD/BD/128032/2016 | por |
dc.relation | UIDB/04469/2020 | por |
dc.relation | UIDB/04050/2020 | por |
dc.rights | restrictedAccess | por |
dc.subject | human disorders | por |
dc.subject | infections | por |
dc.subject | subunit isoforms | por |
dc.subject | therapeutic target | por |
dc.subject | V-ATPase | por |
dc.title | Emerging insights on the role of V-ATPase in human diseases: Therapeutic challenges and opportunities | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/journal/10981128 | por |
dc.comments | CEB54126 | por |
oaire.citationStartPage | 1927 | por |
oaire.citationEndPage | 1964 | por |
oaire.citationIssue | 4 | por |
oaire.citationConferencePlace | United States | - |
oaire.citationVolume | 41 | por |
dc.date.updated | 2021-10-09T11:45:08Z | - |
dc.identifier.doi | 10.1002/med.21782 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 33483985 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Medicinal Research Reviews | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series CBMA - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_54126_1.pdf Acesso restrito! | 2,86 MB | Adobe PDF | Ver/Abrir |