Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/74304
Título: | A review of methods for the reconstruction and analysis of integrated genome-scale models of metabolism and regulation |
Autor(es): | Cruz, Fernando Faria, José Pedro Rocha, Miguel Rocha, Isabel Dias, Oscar |
Palavras-chave: | Flux balance analysis Gene expression and regulation Genome-scale metabolic models Genome-scale regulatory networks Metabolism Transcriptional regulatory networks |
Data: | 17-Set-2020 |
Editora: | Portland Press |
Revista: | Biochemical Society Transactions |
Citação: | Cruz, F., Faria, J. P., Rocha, M., Rocha, I., & Dias, O. (2020). A review of methods for the reconstruction and analysis of integrated genome-scale models of metabolism and regulation. Biochemical Society Transactions, 48(5), 1889-1903 |
Resumo(s): | The current survey aims to describe the main methodologies for extending the reconstruction and analysis of genome-scale metabolic models and phenotype simulation with Flux Balance Analysis mathematical frameworks, via the integration of Transcriptional Regulatory Networks and/or gene expression data. Although the surveyed methods are aimed at improving phenotype simulations obtained from these models, the perspective of reconstructing integrated genome-scale models of metabolism and gene expression for diverse prokaryotes is still an open challenge. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/74304 |
DOI: | 10.1042/bst20190840 |
ISSN: | 0300-5127 |
Versão da editora: | https://portlandpress.com/biochemsoctrans/article-abstract/48/5/1889/226439/A-review-of-methods-for-the-reconstruction-and?redirectedFrom=fulltext |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_53909_1.pdf | 6,35 MB | Adobe PDF | Ver/Abrir |