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https://hdl.handle.net/1822/74013
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Campo DC | Valor | Idioma |
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dc.contributor.author | Franco, Julia Gomes | por |
dc.contributor.author | Cefali, Letícia Caramori | por |
dc.contributor.author | Ataide, Janaína Artem | por |
dc.contributor.author | Santini, Antonello | por |
dc.contributor.author | Souto, Eliana B. | por |
dc.contributor.author | Mazzola, Priscila Gava | por |
dc.date.accessioned | 2021-09-14T09:52:49Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.citation | Franco, Julia Gomes; Cefali, Letícia Caramori; Ataide, Janaína Artem; Santini, Antonello; Souto, Eliana; Mazzola, Priscila Gava, Effect of nanoencapsulation of blueberry (Vaccinium myrtillus): A green source of flavonoids with antioxidant and photoprotective properties. Sustainable Chemistry and Pharmacy, 23(100515), 2021 | por |
dc.identifier.issn | 2352-5541 | por |
dc.identifier.uri | https://hdl.handle.net/1822/74013 | - |
dc.description.abstract | The effect of nanoencapsulation on the in vitro photoprotection and antioxidant properties of blueberry (Vaccinium myrtillus) extract, before and after their dispersion into an oil-in-water emulsion and its final stability under stress conditions. Besides its skin healing activity, chitosan was chosen as wall material due to its natural origin, and possibility of obtention from shrimp residues. Chitosan/tripolyphosphate (TPP) nanoparticles loaded with blueberry extract were produced and characterized. Three different semi-solid oil-in-water emulsions, using Ecocert certified materials, were developed containing, respectively, (i) 5% (wt/wt) of extract-free nanoparticles, (ii) 5% (wt/wt) of extract-loaded nanoparticles, (iii) 2% (wt/wt) of free extract. Sun protection factor (SPF), antioxidant activity and stability under stress conditions were evaluated. The concentration of rutin was determined by High Performance Liquid Chromatography (HPLC). The loading of blueberry extract into nanoparticles kept their physicochemical properties, as well as SPF and antioxidant activity, over the course of the stability study. Extract-loaded nanoparticles were dispersed in a semi-solid oil-in-water emulsion and were shown to protect the extract from oxidation, suggesting that formulation containing 5% (wt/wt) of extract-free nanoparticles could presented lower difference between initial and final SPF and antioxidant activity values after 90 days of analysis. The developed formulation is proposed as a greener potential formulation to be used as photoprotector, especially if associated with physical sun filters. The role of blueberry flavonoids and the synergistic effect of nanoparticles against skin aging are here discussed. | por |
dc.description.sponsorship | This research was funded by FAPESP (grant number 2015/25533–7, 2017/14757–7, 2017/05275–9) and in part by CAPES (Finance Code 001). This study was financed by CNPq (301436/2017–7) granted to PGM, and by the Portuguese Science and Technology Foundation (FCT / MCT) and from European Funds (PRODER/COMPETE) under the project reference UIDB/04469/2020 (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020, granted to EBS. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier BV | por |
dc.relation | UIDB/04469/2020 | por |
dc.rights | restrictedAccess | por |
dc.subject | Flavonoids | por |
dc.subject | Polysaccharide-lipid nanoformulations | por |
dc.subject | Antioxidant | por |
dc.subject | Sun protection factor | por |
dc.subject | Nanoparticles | por |
dc.subject | Vaccinium myrtillus | por |
dc.title | Effect of nanoencapsulation of blueberry (Vaccinium myrtillus): A green source of flavonoids with antioxidant and photoprotective properties | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S235255412100142X | por |
dc.comments | CEB54633 | por |
oaire.citationConferencePlace | Netherlands | - |
oaire.citationVolume | 23 | por |
dc.date.updated | 2021-09-14T08:59:22Z | - |
dc.identifier.doi | 10.1016/j.scp.2021.100515 | por |
dc.date.embargo | 10000-01-01 | - |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Sustainable Chemistry and Pharmacy | por |
dc.identifier.articlenumber | 100515 | - |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
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document_54633_1.pdf Acesso restrito! | 2,55 MB | Adobe PDF | Ver/Abrir |