Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/72610
Título: | Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimers disease |
Autor(es): | Del Amo, Laura Cano, Amanda Ettcheto, Miren Souto, Eliana B. Espina, Marta Camins, Antoni García, Maria Luísa Sánchez-López, Elena |
Palavras-chave: | functionalized PLGA nanoparticles brain delivery blood-brain barrier Alzheimers disease Alzheimer’ s disease Alzheimer’ |
Data: | 10-Mai-2021 |
Editora: | MDPI |
Revista: | Applied Sciences |
Citação: | Del Amo, Laura; Cano, Amanda; Ettcheto, Miren; Souto, Eliana; Espina, Marta; Camins, Antoni; García, Maria Luísa; Sánchez-López, Elena, Surface Functionalization of PLGA Nanoparticles to Increase Transport across the BBB for Alzheimers Disease. Applied Sciences-Basel, 11(9), 4305, 2021 |
Resumo(s): | Alzheimers disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases of dementia worldwide. Although there are currently several drugs marketed for its treatment, none are capable of slowing down or stopping the progression of AD. The role of the blood-brain barrier (BBB) plays a key role in the design of a successful treatment for this neurodegenerative disease. Nanosized particles have been proposed as suitable drug delivery systems to overcome BBB with the purpose of increasing bioavailability of drugs in the brain. Biodegradable poly (lactic-co-glycolic acid) nanoparticles (PLGA-NPs) have been particularly regarded as promising drug delivery systems as they can be surface-tailored with functionalized molecules for site-specific targeting. In this review, a thorough discussion about the most recent functionalization strategies based on PLGA-NPs for AD and their mechanisms of action is provided, together with a description of AD pathogenesis and the role of the BBB in brain targeting. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/72610 |
DOI: | 10.3390/app11094305 |
ISSN: | 2076-3417 |
Versão da editora: | https://www.mdpi.com/2076-3417/11/9/4305 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54422_1.pdf | 12,06 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons