Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/72047
Título: | Endocytosis of nutrient transporters in fungi: the ART of connecting signaling and trafficking |
Autor(es): | Barata-Antunes, Cláudia Alves, R. Talaia, Gabriel Casal, Margarida Gerós, H. Mans, Robert Paiva, Sandra |
Palavras-chave: | Fungi Nutrient transporters Endocytosis Arrestins Ubiquitylation Endocytic signals Metabolism Signaling pathways Conformational changes MCCs/eisosomes Structure-function Biotechnology Cell factories Saccharomyces cerevisiae Aspergilli |
Data: | 2021 |
Editora: | Elsevier 1 |
Revista: | Computational and Structural Biotechnology Journal |
Citação: | Barata-Antunes, Cláudia; Alves, R.; Talaia, Gabriel; Casal, Margarida; Gerós, Hernâni; Mans, Robert; Paiva, Sandra, Endocytosis of nutrient transporters in fungi: the ART of connecting signaling and trafficking. Computational and Structural Biotechnology Journal, 19, 1713-1737, 2021 |
Resumo(s): | Plasma membrane transporters play pivotal roles in the import of nutrients, including sugars, amino acids, nucleobases, carboxylic acids, and metal ions, that surround fungal cells. The selective removal of these transporters by endocytosis is one of the most important regulatory mechanisms that ensures a rapid adaptation of cells to the changing environment (e.g., nutrient fluctuations or different stresses). At the heart of this mechanism lies a network of proteins that include the arrestin?related trafficking adaptors (ARTs) which link the ubiquitin ligase Rsp5 to nutrient transporters and endocytic factors. Transporter conformational changes, as well as dynamic interactions between its cytosolic termini/loops and with lipids of the plasma membrane, are also critical during the endocytic process. Here, we review the current knowledge and recent findings on the molecular mechanisms involved in nutrient transporter endocytosis, both in the budding yeast Saccharomyces cerevisiae and in some species of the filamentous fungus Aspergillus. We elaborate on the physiological importance of tightly regulated endocytosis for cellular fitness under dynamic conditions found in nature and highlight how further understanding and engineering of this process is essential to maximize titer, rate and yield (TRY)-values of engineered cell factories in industrial biotechnological processes. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/72047 |
DOI: | 10.1016/j.csbj.2021.03.013 |
ISSN: | 2001-0370 |
Versão da editora: | https://www.sciencedirect.com/journal/computational-and-structural-biotechnology-journal |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_54304_1.pdf Acesso restrito! | 5,28 MB | Adobe PDF | Ver/Abrir |