Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/71119
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Monteiro-Reis, Sara | por |
dc.contributor.author | Carvalho-Maia, Carina | por |
dc.contributor.author | Bart, Genevieve | por |
dc.contributor.author | Vainio, Seppo J. | por |
dc.contributor.author | Pedro, Juliana | por |
dc.contributor.author | Silva, Eunice R. | por |
dc.contributor.author | Sales, M. G. F. | por |
dc.contributor.author | Henrique, Rui | por |
dc.contributor.author | Jerónimo, Carmen | por |
dc.date.accessioned | 2021-03-30T23:48:41Z | - |
dc.date.available | 2021-03-30T23:48:41Z | - |
dc.date.issued | 2021-03-23 | - |
dc.identifier.citation | Monteiro-Reis, Sara; Carvalho-Maia, Carina; Bart, Genevieve; Vainio, Seppo J.; Pedro, Juliana; Silva, Eunice R.; Sales, M. G. F.; Henrique, Rui; Jerónimo, Carmen, Secreted extracellular vesicle molecular cargo as a novel liquid biopsy diagnostics of central nervous system diseases. International Journal of Molecular Sciences, 22(6), 3267, 2021 | por |
dc.identifier.isbn | 1424-6783 | - |
dc.identifier.issn | 14220067 | por |
dc.identifier.uri | https://hdl.handle.net/1822/71119 | - |
dc.description.abstract | Secreted extracellular vesicles (EVs) are heterogeneous cell-derived membranous granules which carry a large diversity of molecules and participate in intercellular communication by transferring these molecules to target cells by endocytosis. In the last decade, EVs role in several pathological conditions, from etiology to disease progression or therapy evasion, has been consolidated, including in central nervous system (CNS)-related disorders. For this review, we performed a systematic search of original works published, reporting the presence of molecular components expressed in the CNS via EVs, which have been purified from plasma, serum or cerebrospinal fluid. Our aim is to provide a list of molecular EV components that have been identified from both nonpathological conditions and the most common CNS-related disorders. We discuss the methods used to isolate and enrich EVs from specific CNS-cells and the relevance of its components in each disease context. | por |
dc.description.sponsorship | This research was funded by the MindGaP-H2020-FETOPEN-2018-2020, Grant agreement ID: 829040. S.M.-R., C.C.-M., and J.P. hold a fellowship from MindGaP. | por |
dc.language.iso | eng | por |
dc.publisher | MDPI | por |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/829040/EU | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | extracellular vesicles | por |
dc.subject | central nervous system | por |
dc.subject | biomarkers | por |
dc.title | Secreted extracellular vesicle molecular cargo as a novel liquid biopsy diagnostics of central nervous system diseases | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/22/6/3267 | por |
dc.comments | CEB54355 | por |
oaire.citationStartPage | 3267 | por |
oaire.citationIssue | 6 | por |
oaire.citationConferencePlace | Switzerland | - |
oaire.citationVolume | 22 | por |
dc.date.updated | 2021-03-30T23:10:36Z | - |
dc.identifier.doi | 10.3390/ijms22063267 | por |
dc.identifier.pmid | 33806874 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | International Journal of Molecular Sciences | por |
oaire.version | VoR | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54355_1.pdf | 1,73 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons