Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/69836
Título: | Organ-on-a-chip: a preclinical microfluidic platform for the progress of nanomedicine |
Autor(es): | Rodrigues, Raquel Oliveira Sousa, Patrícia C. Gaspar, João Bañobre-López, Manuel Lima, Rui Alberto Madeira Macedo Minas, Graça |
Palavras-chave: | Organ-on-a-chip Nanoparticles biosensors theranostics tissue engineering organ‐ on‐ a‐ chip |
Data: | Dez-2020 |
Editora: | Wiley |
Revista: | Small |
Citação: | Rodrigues, R. O., Sousa, P. C., Gaspar, J., Bañobre-López, M., Lima, R., Minas, G., Organ-on-a-Chip: A Preclinical Microfluidic Platform for the Progress of Nanomedicine. Small 2020, 16, 2003517. https://doi.org/10.1002/smll.202003517 |
Resumo(s): | Despite the progress achieved in nanomedicine during the last decade, the translation of new nanotechnology-based therapeutic systems into clinical applications has been slow, especially due to the lack of robust preclinical tissue culture platforms able to mimic the in vivo conditions found in the human body and to predict the performance and biotoxicity of the developed nanomaterials. Organ-on-a-chip (OoC) platforms are novel microfluidic tools that mimic complex human organ functions at the microscale level. These integrated microfluidic networks, with 3D tissue engineered models, have been shown high potential to reduce the discrepancies between the results derived from preclinical and clinical trials. However, there are many challenges that still need to be addressed, such as the integration of biosensor modules for long-time monitoring of different physicochemical and biochemical parameters. In this review, recent advances on OoC platforms, particularly on the preclinical validation of nanomaterials designed for cancer, as well as the current challenges and possible future directions for an end-use perspective are discussed. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/69836 |
DOI: | 10.1002/smll.202003517 |
ISSN: | 1613-6810 |
e-ISSN: | 1613-6829 |
Versão da editora: | https://onlinelibrary.wiley.com/doi/pdf/10.1002/smll.202003517 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CMEMS - Artigos em revistas internacionais/Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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smll.202003517.pdf Acesso restrito! | Texto Integral | 2,27 MB | Adobe PDF | Ver/Abrir |