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https://hdl.handle.net/1822/68528
Título: | Data on the effects of Hyptis spp. and Lycium spp. plant extracts in C. elegans models of genetically determined neurodegenerative diseases |
Autor(es): | Vilasboas-Campos, Daniela Costa, Marta Daniela Teixeira-Castro, Andreia Rios, Rejaine Silva, Fabiano Guimarães Aierken, Aili Zhang, Xiaoying Bessa, Carlos Dias, Alberto Maciel, P. |
Palavras-chave: | Neurodegeneration Neuroprotection Antioxidant properties C. elegans Hyptis spp. Lycium spp. Plant extracts |
Data: | Dez-2020 |
Editora: | Elsevier 1 |
Revista: | Data in Brief |
Citação: | Vilasboas-Campos, Daniela; Costa, Marta Daniela; Teixeira-Castro, Andreia; Rios, Rejaine; Silva, Fabiano Guimarães; Aierken, Aili; Zhang, Xiaoying; Bessa, Carlos; Dias, Alberto; Maciel, Patrícia, Data on the effects of Hyptis spp. and Lycium spp. plant extracts in C. elegans models of genetically determined neurodegenerative diseases. Data in Brief, 33(106598), 2020. DOI: 10.1016/j.dib.2020.106598 |
Resumo(s): | Here, we present the data on the biological effects of Hyptis spp. and Lycium spp. plant extracts in Caenorhabditis elegans (C. elegans) models of neurodegenerative diseases, which is related to the work presented in the article "Neurotherapeutic effect of Hyptis spp. leaf extracts in Caenorhabditis elegans models of tauopathy and polyglutamine disease: role of the glutathione redox cycle" [1]. This dataset was generated to define non-toxic concentrations of these plant extracts and to assess their impact on the motor phenotype and oxidative stress resistance of transgenic C. elegans models of two genetically defined neurodegenerative diseases: Machado-Joseph disease and Frontotemporal dementia with Parkinsonism associated to the chromosome 17. The impact of the plant extracts on toxicity was assessed using the food-clearance assay, absorbance being measured daily for seven days at 595 nm to quantify Escherichia coli (E. coli) strain OP50 bacteria consumption. Worm length and motor behaviour, including spontaneous and stimulated movement, were analysed using videos acquired with an Olympus SZX7 stereomicroscope with an integrated camera (Olympus SC30) and processed using the Image J® software and the Wrmtrck plugin. The resistance to oxidative stress induced by 240 µM juglone was assessed by determining the percentage of live animals after 1 hour of exposure. |
Tipo: | Artigo |
Descrição: | Supplementary material associated with this article can be found in the online version at: doi:10.1016/j.dib.2020.106598. |
URI: | https://hdl.handle.net/1822/68528 |
DOI: | 10.1016/j.dib.2020.106598 |
ISSN: | 2352-3409 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S2352340920314785 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series ICVS - Artigos em revistas internacionais / Papers in international journals CBMA - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54012_1.pdf | 1,63 MB | Adobe PDF | Ver/Abrir |