Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/67987
Título: | Bacteriophages to control Shiga toxin-producing E. coli safety and regulatory challenges |
Autor(es): | Pinto, Graça Almeida, Carina Azeredo, Joana |
Palavras-chave: | STEC bacteriophage food biocontrol safety regulatory guidelines gut |
Data: | 2020 |
Editora: | Taylor and Francis |
Revista: | Critical Reviews in Biotechnology |
Citação: | Pinto, Graça; Almeida, Carina; Azeredo, Joana, Bacteriophages to control Shiga toxin-producing E. coli safety and regulatory challenges. Critical Reviews in Biotechnology, 4(8), 1081-1097, 2020 |
Resumo(s): | Shiga toxin-producing Escherichia coli (STEC) are usually found on food products due to contamination from the fecal origin, as their main environmental reservoir is considered to be the gut of ruminants. While this pathogen is far from the incidence of other well-known foodborne bacteria, the severity of STEC infections in humans has triggered global concerns as far as its incidence and control are concerned. Major control strategies for foodborne pathogens in food-related settings usually involve traditional sterilization/disinfection techniques. However, there is an increasing need for the development of further strategies to enhance the antimicrobial outcome, either on food-contact surfaces or directly in food matrices. Phages are considered to be a good alternative to control foodborne pathogens, with some phage-based products already cleared by the Food and Drug Administration (FDA) to be used in the food industry. In European countries, phage-based food decontaminants have already been used. Nevertheless, its broad use in the European Union is not yet possible due to the lack of specific guidelines for the approval of these products. Furthermore, some safety concerns remain to be addressed so that the regulatory requirements can be met. In this review, we present an overview of the main virulence factors of STEC and introduce phages as promising biocontrol agents for STEC control. We further present the regulatory constraints on the approval of phages for food applications and discuss safety concerns that are still impairing their use. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/67987 |
DOI: | 10.1080/07388551.2020.1805719 |
ISSN: | 0738-8551 |
e-ISSN: | 1549-7801 |
Versão da editora: | http://informahealthcare.com/journal/bty |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_53869_1.pdf | 2,4 MB | Adobe PDF | Ver/Abrir |