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https://hdl.handle.net/1822/67666
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Costa, Sandra | por |
dc.contributor.author | Pinto, Daniela | por |
dc.contributor.author | Pereira, Deolinda | por |
dc.contributor.author | Rodrigues, Helena | por |
dc.contributor.author | Cameselle-Teijeiro, Jorge | por |
dc.contributor.author | Medeiros, Rui | por |
dc.contributor.author | Schmitt, Fernando | por |
dc.date.accessioned | 2020-10-23T15:58:41Z | - |
dc.date.issued | 2007-06 | - |
dc.identifier.issn | 0167-6806 | - |
dc.identifier.uri | https://hdl.handle.net/1822/67666 | - |
dc.description.abstract | The purpose of this study was to evaluate the role of polymorphisms in DNA repair genes as genetic indicators of susceptibility to familial and sporadic breast cancer. We analysed DNA samples from 285 breast cancer patients and 442 control subjects, for XRCC1 Arg399Gln, XPD Lys751Gln, RAD51 G135C and XRCC3 Thr241Met polymorphisms using PCR-RFLP. We observed that women carriers of XRCC1 399Gln genotypes and without family history of breast cancer have a protective effect concerning this disease (OR = 0.54 95% CI 0.35-0.84; p = 0.006). Furthermore, we found that carriers of XRCC3 241Met genotypes without FH have an increased susceptibility of breast cancer (OR = 2.21 95% CI 1.42-3.44; p < 0.001). Additionally, we verified an increased risk of breast cancer in women with FH and carrying RAD51 135C genotypes (OR = 2.17 95% CI 1.19-3.98; p = 0.012). Our results suggest XRCC1 Arg399Gln and XRCC3 Thr241Met DNA repair polymorphisms as important biomarkers to sporadic breast cancer susceptibility, as well as, RAD51 G135C polymorphism as a real risk modifier in familial breast cancer cases. | por |
dc.description.sponsorship | he authors would like to thank toOncology and Surgical Department from S. Joa ̃o Hospital atPorto, to Pathology Departments of the different Hospitalsinvolved. We would like to thank to ImunohemotherapyDepartment of S. Marcos Hospital at Braga and Dr. Ma ́rioJoa ̃o for their helpful assistance in the management of con-trols. We gratefully acknowledge funding of this work by theFLAD (Fundac ̧a ̃o Luso-Americana para o Desenvolvimento),by the Minister of Health of Portugal (Comissa ̃o de Fomentoda Investigaca ̃o em Cuidados de Sau ́de: CFICS-226/01), AstraZeneca Foundation and Calouste Gulbenkian Foundation. Wealso gratefully acknowledge for financial support of individualgrant for Doctoral degree of the first author to Minister of Science, Technology and Superior Education-FCT (Fundac ̧a ̃opara a Cieˆncia e Tecnologia: SFRH/BD/9758/2003). | por |
dc.language.iso | eng | por |
dc.publisher | Springer | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F9758%2F2003/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | Adult | por |
dc.subject | Aged | por |
dc.subject | Aged, 80 and over | por |
dc.subject | Breast neoplasms | por |
dc.subject | DNA repair | por |
dc.subject | DNA-Binding proteins | por |
dc.subject | Female | por |
dc.subject | Gene frequency | por |
dc.subject | Humans | por |
dc.subject | Middle aged | por |
dc.subject | Rad51 recombinase | por |
dc.subject | X-ray Repair Cross Complementing Protein 1 | por |
dc.subject | Xeroderma Pigmentosum Group D Protein | por |
dc.subject | Genetic predisposition to disease | por |
dc.subject | Polymorphism, Genetic | por |
dc.subject | Familial | por |
dc.subject | Sporadic | por |
dc.subject | Breast | por |
dc.subject | Risk | por |
dc.subject | XRCC1 | por |
dc.subject | XRCC3 | por |
dc.subject | RAD51 | por |
dc.subject | XPD | por |
dc.subject | polymorphisms | por |
dc.title | DNA repair polymorphisms might contribute differentially on familial and sporadic breast cancer susceptibility: a study on a Portuguese population | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s10549-006-9364-z | por |
oaire.citationStartPage | 209 | por |
oaire.citationEndPage | 217 | por |
oaire.citationIssue | 2 | por |
oaire.citationVolume | 103 | por |
dc.identifier.eissn | 1573-7217 | - |
dc.identifier.doi | 10.1007/s10549-006-9364-z | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 17063276 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Breast Cancer Research and Treatment | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Costa-2007-Dna-repair-polymorphisms-might-cont.pdf Acesso restrito! | 273,11 kB | Adobe PDF | Ver/Abrir |