Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/67591
Título: | Chemokine binding proteins encoded by pathogens |
Autor(es): | Alcami, Antonio Saraiva, Margarida |
Palavras-chave: | Animals Anti-inflammatory agents Chemokines Humans Protein binding Receptors, Chemokine Viral proteins Virus diseases |
Data: | 2009 |
Editora: | Springer Nature |
Revista: | Advances in Experimental Medicine and Biology |
Resumo(s): | Chemokines are chemoattractant cytokines that play an important role in immunity. The role of chemokines against invading pathogens is emphasized by the expression of chemokine inhibitors by many pathogens. A mechanims employed by poxviruses and herpesviruses is the secretion of chemokine bindingproteins unrelated to host receptors that bind chemokines with high affinity and block their activity. Soluble chemokine binding proteins have also been identified in the human parasite Schistosoma mansoni and in ticks. The binding specificity of these inhibitors of cell migration point at chemokines that contribute to host defense mechanisms against various pathogens. Chemokine binding proteins modulate the immune response and may lead to new therapeutic approaches to treat inflamatory diseases. |
Tipo: | Capítulo de livro |
URI: | https://hdl.handle.net/1822/67591 |
ISBN: | 978-1-4419-1600-6 |
e-ISBN: | 978-1-4419-1601-3 |
DOI: | 10.1007/978-1-4419-1601-3_13 |
ISSN: | 0065-2598 |
Versão da editora: | https://link.springer.com/chapter/10.1007/978-1-4419-1601-3_13 |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
10.1007_978-1-4419-1601-3_13.pdf Acesso restrito! | 1,2 MB | Adobe PDF | Ver/Abrir |