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https://hdl.handle.net/1822/67567
Título: | Up-regulation of 14-3-3sigma (Stratifin) is associated with high-grade CIN and high-risk human papillomavirus (HPV) at baseline but does not predict outcomes of HR-HPV infections or incident CIN in the LAMS study |
Autor(es): | Syrjänen, Stina Naud, Paulo Sarian, Luis Derchain, Sophie Roteli-Martins, Cecilia Longatto, Adhemar Tatti, Silvio Branca, Margerita Erzen, Mojca Hammes, Luciano S Costa, Silvano Syrjänen, Kari |
Palavras-chave: | 14-3-3 Proteins Alphapapillomavirus Biomarkers, Tumor Biopsy Cervical Intraepithelial Neoplasia Exonucleases Exoribonucleases Female Humans Multicenter Studies as Topic Neoplasm Proteins Papillomavirus Infections Treatment Outcome Up-Regulation High-risk human papillomavirus Stratifin 14-3-3σ Cell cycle control Inactivation Overexpression Epigenetic Viral outcomes Disease progression Longitudinal predictive values Surrogate end points 14-3-3 sigma |
Data: | Fev-2010 |
Editora: | Oxford University Press |
Revista: | American Journal of Clinical Pathology |
Resumo(s): | To assess whether the potentially high-risk (HR) human papillomavirus (HPV)-related up-regulation of 14-3-3sigma (stratifin) has implications in the outcome of HPV infections or cervical intraepithelial neoplasia (CIN) lesions, cervical biopsy specimens from 225 women in the Latin American Screening Study were analyzed for 14-3-3sigma expression using immunohistochemical analysis. We assessed its associations with CIN grade and HR HPV at baseline and value in predicting outcomes of HR-HPV infections and the development of incident CIN 1+ and CIN 2+. Expression of 14-3-3sigma increased in parallel with the lesion grade. Up-regulation was also significantly related to HR-HPV detection (P = .004; odds ratio, 2.71; 95% confidence interval, 1.37-5.35) and showed a linear relationship to HR-HPV loads (P = .003). 14-3-3sigma expression was of no value in predicting the outcomes (incident, persistent, clearance) of HR-HPV infections or incident CIN 1+ and CIN 2+. 14-3-3sigma is not inactivated in cervical carcinoma and CIN but is up-regulated on transition from CIN 2 to CIN 3. Its normal functions in controlling G(1)/S and G(2)/M checkpoints are being bypassed by HR HPV. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/67567 |
DOI: | 10.1309/AJCP49DOITYDCTQJ |
ISSN: | 1943-7722 |
e-ISSN: | 0002-9173 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Syrjanen-2010-Up-regulation-of-stratifin-is-as.pdf | 460,22 kB | Adobe PDF | Ver/Abrir |