Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/67552

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dc.contributor.authorPêgo, José M.por
dc.contributor.authorSousa, João Carlospor
dc.contributor.authorAlmeida, O. F. X.por
dc.contributor.authorSousa, Nunopor
dc.date.accessioned2020-10-16T16:30:06Z-
dc.date.issued2010-
dc.identifier.citationPego, J. M., Sousa, J. C., Almeida, O. F. X., et. al. (2009). Stress and the neuroendocrinology of anxiety disorders. In Behavioral Neurobiology of Anxiety and its Treatment (pp. 97-118)por
dc.identifier.isbn978-3-642-02911-0por
dc.identifier.issn1866-3370por
dc.identifier.urihttp://hdl.handle.net/1822/67552-
dc.description.abstractStress is a risk factor for depressive and anxiety disorders. Changes in lifestyle patterns that are associated with increased stress therefore place a greater burden on mental health. Stress challenges the organism's homeostatic mechanisms, triggering a cascade of events that should, normally, maintain or allow a return to equilibrium. Stressful events are perceived by sensory systems in the brain, facilitating evaluation and comparison of the existing and previous stimuli as well as the activation of hormones responsible for energy mobilization. The limbic system coordinates the release of corticosteroids, the primary stress hormones, by modulating activation of the hypothalamic paraventricular nucleus (PVN). The amygdala, a limbic structure related to emotional behavior, has a putative role in the evaluation of emotional events and formation of fearful memories; it is also a target of the neurochemical and hormonal mediators of stress. Clinical and experimental data have correlated changes in the structure/function of the amygdala with emotional disorders such as anxiety. In this chapter we review the neuroendocrinology of the stress response, focusing on the role of the limbic system in its establishment and supplementing that information with new experimental data that demonstrates the relationship between stress and anxiety disorders; we also discuss the structural changes that occur in the amygdala after stress.por
dc.language.isoengpor
dc.publisherSpringerpor
dc.rightsrestrictedAccesspor
dc.subjectAdrenal Cortex Hormonespor
dc.subjectAmygdalapor
dc.subjectAnimalspor
dc.subjectAnxiety Disorderspor
dc.subjectHumanspor
dc.subjectLimbic Systempor
dc.subjectParaventricular Hypothalamic Nucleuspor
dc.subjectRisk Factorspor
dc.subjectStress, Psychologicalpor
dc.subjectEmotionspor
dc.subjectLife Change Eventspor
dc.subjectCorticosteroidspor
dc.subjectBed Nucleus of the Stria Terminalispor
dc.subjectRatpor
dc.subjectAnxietypor
dc.subjectStresspor
dc.subjectAnimal Modelspor
dc.titleStress and the neuroendocrinology of anxiety disorderspor
dc.typebookPartpor
dc.relation.publisherversionhttps://link.springer.com/chapter/10.1007/7854_2009_13por
oaire.citationStartPage97por
oaire.citationEndPage118por
oaire.citationVolume2por
dc.identifier.doi10.1007/7854_2009_13por
dc.date.embargo10000-01-01-
dc.identifier.esbn978-3-642-02912-7por
dc.identifier.pmid21309108por
dc.subject.fosCiências Médicas::Medicina Básicapor
dc.subject.wosScience & Technologypor
sdum.journalCurrent Topics in Behavioral Neurosciences-
sdum.conferencePublicationBEHAVIORAL NEUROBIOLOGY OF ANXIETY AND ITS TREATMENTpor
Appears in Collections:ICVS - Livros e capítulos de Livros / Books and book chapters

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