Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/67463
Título: | The reductive glycine pathway allows autotrophic growth of Desulfovibrio desulfuricans |
Autor(es): | Sánchez-Andrea, Irene Guedes, Iame Alves Hornung, Bastian Boeren, Sjef Lawson, Christopher E. Sousa, Diana Zita Machado Bar-Even, Arren Claassens, Nico J. Stams, Alfons Johannes Maria |
Data: | 2020 |
Editora: | Springer Nature |
Revista: | Nature Communications |
Citação: | Sánchez-Andrea, Irene; Guedes, Iame Alves; Hornung, Bastian; Boeren, Sjef; Lawson, Christopher E.; Sousa, Diana Z.; Bar-Even, Arren; Claassens, Nico J.; Stams, A. J. M., The reductive glycine pathway allows autotrophic growth of Desulfovibrio desulfuricans. Nature Communications, 11(5090), 2020 |
Resumo(s): | Six CO2 fixation pathways are known to operate in photoautotrophic and chemoautotrophic microorganisms. Here, we describe chemolithoautotrophic growth of the sulphate-reducing bacterium Desulfovibrio desulfuricans (strain G11) with hydrogen and sulphate as energy substrates. Genomic, transcriptomic, proteomic and metabolomic analyses reveal that D. desulfuricans assimilates CO2 via the reductive glycine pathway, a seventh CO2 fixation pathway. In this pathway, CO2 is first reduced to formate, which is reduced and condensed with a second CO2 to generate glycine. Glycine is further reduced in D. desulfuricans by glycine reductase to acetyl-P, and then to acetyl-CoA, which is condensed with another CO2 to form pyruvate. Ammonia is involved in the operation of the pathway, which is reflected in the dependence of the autotrophic growth rate on the ammonia concentration. Our study demonstrates microbial autotrophic growth fully supported by this highly ATP-efficient CO2 fixation pathway. |
Tipo: | Artigo |
Descrição: | Supplementary informationis available for this paper athttps://doi.org/10.1038/s41467-020-18906-7 |
URI: | https://hdl.handle.net/1822/67463 |
DOI: | 10.1038/s41467-020-18906-7 |
ISSN: | 2041-1723 |
Versão da editora: | https://www.nature.com/articles/s41467-020-18906-7 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_53935_1.pdf | 1,87 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons