Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/67350
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Silva, Rita Ribeiro | por |
dc.contributor.author | Goios, Ana | por |
dc.contributor.author | Kelly, Christine | por |
dc.contributor.author | Teixeira, Pedro | por |
dc.contributor.author | João, Cristina | por |
dc.contributor.author | Horta, Ana Maria Lacerda Morgado Fernandes Carvalho Aboim | por |
dc.contributor.author | Correia-Neves, M | por |
dc.date.accessioned | 2020-10-07T16:32:33Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Rb-Silva, R., Goios, A., Kelly, C., Teixeira, P., et. al.(2019). Definition of immunological nonresponse to antiretroviral therapy: a systematic review. JAIDS Journal of Acquired Immune Deficiency Syndromes, 82(5), 452-461 | por |
dc.identifier.issn | 1525-4135 | - |
dc.identifier.uri | https://hdl.handle.net/1822/67350 | - |
dc.description.abstract | Terms and criteria to classify people living with HIV on antiretroviral therapy who fail to achieve satisfactory CD4 T-cell counts are heterogeneous, and need revision and summarization. Background: Terms and criteria to classify people living with HIV on antiretroviral therapy who fail to achieve satisfactory CD4+ T-cell counts are heterogeneous, and need revision and summarization. Methods: We performed a systematic review of PubMed original research articles containing a set of predefined terms, published in English between January 2009 and September 2018. The search retrieved initially 1360 studies, of which 103 were eligible. The representative terminology and criteria were extracted and analyzed. Results: Twenty-two terms and 73 criteria to define the condition were identified. The most frequent term was “immunological nonresponders” and the most frequent criterion was “CD4+ T-cell count <350 cells/µL after ≥24 months of virologic suppression.” Most criteria use CD4+ T-cell counts as a surrogate, either as an absolute value before antiretroviral therapy initiation or as a change after a defined period of time. Distinct values and time points were used. Only 9 of the 73 criteria were used by more than one independent research team. Herein we propose 2 criteria that could help to reach a consensus. Conclusions: The high disparity in terms and criteria here reported precludes data aggregation and progression of the knowledge on this condition, because it renders impossible to compare data from different studies. This review will foster the discussion of terms and criteria to achieve a consensual definition. | por |
dc.description.sponsorship | Supported by: FEDER, through the Competitiveness Factors Operational Program (COMPETE); by National funds, through the Foundation for Science and Technology (FCT), under the scope of the project POCI-01-0145-FEDER-007038 and NORTE-01-0145-FEDER-000013; and by Programa Gilead GENESE (PGG/018/2017). R.R.-S. was supported by an FCT grant, in the context of PhDOC-Doctoral Program in Ageing and Chronic Diseases (PD/BD/106047/2015). | por |
dc.language.iso | eng | por |
dc.publisher | Lippincott, Williams & Wilkins | por |
dc.rights | restrictedAccess | por |
dc.subject | Anti-HIV Agents | por |
dc.subject | CD4 Lymphocyte Count | por |
dc.subject | HIV Infections | por |
dc.subject | Humans | por |
dc.subject | Sustained Virologic Response | por |
dc.subject | Terminology as Topic | por |
dc.subject | Antiretroviral therapy | por |
dc.subject | Immune recovery | por |
dc.subject | CD4+ T-cell count | por |
dc.subject | Immunological nonresponders | por |
dc.subject | Systematic review | por |
dc.subject | HIV infection | por |
dc.title | Definition of immunological nonresponse to antiretroviral therapy: a systematic review | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://journals.lww.com/jaids/Abstract/2019/12150/Definition_of_Immunological_Nonresponse_to.5.aspx | por |
oaire.citationStartPage | 452 | por |
oaire.citationEndPage | 461 | por |
oaire.citationIssue | 5 | por |
oaire.citationVolume | 82 | por |
dc.identifier.eissn | 1944-7884 | - |
dc.identifier.doi | 10.1097/QAI.0000000000002157 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 31592836 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Jaids-Journal of Acquired Immune Deficiency Syndromes | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Rb-silva-2019-Definition-of-immunological-nonresp.pdf Acesso restrito! | 205,44 kB | Adobe PDF | Ver/Abrir |