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https://hdl.handle.net/1822/64289
Título: | Induction of a hyperanxious state by antenatal dexamethasone: a case for less detrimental natural corticosteroids |
Autor(es): | Oliveira, Mário Jorge Alves Bessa, João M. Mesquita, Ana Tavares, Hugo Miguel Braga Almeida Carvalho, André Filipe Couto Silva, Rui Pêgo, José M. Cerqueira, João José Palha, Joana Almeida Almeida, Osborne F. X. Sousa, Nuno |
Palavras-chave: | Adrenal Cortex Hormones Age Factors Animals Anxiety Disorders Behavior, Animal Birth Weight Depression Dexamethasone Disease Models, Animal Dose-Response Relationship, Drug Exploratory Behavior Female Freezing Reaction, Cataleptic Helplessness, Learned Hypothalamo-Hypophyseal System Male Maternal Deprivation Memory Pituitary-Adrenal System Pregnancy Rats Rats, Wistar Sex Factors Spatial Behavior Prenatal Exposure Delayed Effects Neurodevelopment Corticosteroids Antenatal corticotherapy Anxiety Depression Cognition |
Data: | 1-Mai-2006 |
Editora: | Elsevier 1 |
Revista: | Biological Psychiatry |
Resumo(s): | Background: Synthetic glucocorticoids are commonly prescribed during pregnancy, despite a lack of systematic investigations of their potential impact on the developing brain and neurological and behavioral performance. Methods: Neuroendocrine parameters and behavior in the adult offspring of pregnant Wistar rats treated antenatally with either dexamethasone (DEX) or corticosterone (CORT) were monitored; DEX (.1 mg/kg and 1 mg/kg) and CORT (25 mg/kg) were given to pregnant rat dams on gestation days 18 and 19. Results: Despite normal basal levels of corticosterone, the adult offspring of mothers given DEX or CORT displayed abnormal responses in the dexamethasone-suppression test. Neither treatment influenced spatial memory performance, but both DEX and CORT facilitated development of depressionlike behavior following chronic stress. The latter finding demonstrates that high-dose antenatal corticotherapy can impair the organism’s resilience to stress in adulthood. Interestingly, comparison of the progeny of CORT-treated and DEX-treated mothers revealed that the latter were more anxious. Conclusions: Since DEX and CORT differ in their affinity for glucocorticoid and mineralocorticoid receptors and corticosteroidbinding globulin, our findings emphasize the need to consider the pharmacologic properties of antenatal corticotherapies and demonstrate the potential long-term benefits of ligands that can bind to both receptors. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/64289 |
DOI: | 10.1016/j.biopsych.2005.08.020 |
ISSN: | 0006-3223 |
e-ISSN: | 1873-2402 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Oliveira-2006-Induction-of-a-hyperanxious-state-b.pdf Acesso restrito! | 858,75 kB | Adobe PDF | Ver/Abrir |