Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma

doi:10.1007/s13402-019-00426-2

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/62454

Título:	Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma
Autor(es):	Afonso, Julieta Alexandra Pereira Pinto, Tatiana Sousa, Susana Patrícia Simões Schmitt, Fernando Longatto, Adhemar Pinheiro, Céline Marques, Herlander Baltazar, Fátima
Palavras-chave:	Non-Hodgkin lymphoma Diffuse large B cell lymphoma Warburg effect Monocarboxylate transporters Metabolic symbiosis AZD3965
Data:	Jun-2019
Editora:	Springer Verlag
Revista:	Cellular Oncology
Citação:	Afonso, J., Pinto, T., Simões-Sousa, S., Schmitt, F., Longatto-Filho, A., Pinheiro, C., ... & Baltazar, F. (2019). Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma–MCT1 as potential target in diffuse large B cell lymphoma. Cellular Oncology, 1-16
Resumo(s):	Increased glycolytic activity with accumulation of extracellular lactate is regarded as a hallmark of cancer. In lymphomas, FDG-PET has undeniable diagnostic and prognostic value, corroborating that these tumours are avid for glucose. However, the role of glycolytic metabolism-related molecules in lymphoma is not well known. Here, we aimed to evaluate the clinical and prognostic significance of a panel of glycolytic metabolism-related molecules in primary non-Hodgkin lymphomas (NHL) and to test in vitro the putative therapeutic impact of lactate transport inhibition.
Tipo:	Artigo
URI:	https://hdl.handle.net/1822/62454
DOI:	10.1007/s13402-019-00426-2
ISSN:	2211-3428
e-ISSN:	2211-3436
Versão da editora:	https://link.springer.com/article/10.1007/s13402-019-00426-2
Arbitragem científica:	yes
Acesso:	Acesso aberto
Aparece nas coleções:	ICVS - Artigos em revistas internacionais / Papers in international journals