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https://hdl.handle.net/1822/62234
Título: | Patterning in time and space: HoxB cluster gene expression in the developing chick embryo |
Autor(es): | Gouveia, Analuce Canha Marcelino, Hugo Miguel Rocha Gonçalves, Lisa Palmeirim, Isabel Andrade, Raquel P. |
Palavras-chave: | Animals Chick Embryo Chickens Embryonic Development Gene Expression Regulation, Developmental Homeodomain Proteins In Situ Hybridization Mesoderm Hox genes Hox code spatial collinearity temporal collinearity temporal control |
Data: | 2015 |
Editora: | Taylor & Francis |
Revista: | Cell Cycle |
Citação: | Gouveia, A., Marcelino, H. M., Gonçalves, L., Palmeirim, I., & Andrade, R. P. (2015). Patterning in time and space: HoxB cluster gene expression in the developing chick embryo. Cell Cycle, 14(1), 135-145. |
Resumo(s): | The developing embryo is a paradigmatic model to study molecular mechanisms of time control in Biology. Hox genes are key players in the specification of tissue identity during embryo development and their expression is under strict temporal regulation. However, the molecular mechanisms underlying timely Hox activation in the early embryo remain unknown. This is hindered by the lack of a rigorous temporal framework of sequential Hox expression within a single cluster. Herein, a thorough characterization of HoxB cluster gene expression was performed over time and space in the early chick embryo. Clear temporal collinearity of HoxB cluster gene expression activation was observed. Spatial collinearity of HoxB expression was evidenced in different stages of development and in multiple tissues. Using embryo explant cultures we showed that HoxB2 is cyclically expressed in the rostral presomitic mesoderm with the same periodicity as somite formation, suggesting a link between timely tissue specification and somite formation. We foresee that the molecular framework herein provided will facilitate experimental approaches aimed at identifying the regulatory mechanisms underlying Hox expression in Time and Space. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/62234 |
DOI: | 10.4161/15384101.2014.972868 |
ISSN: | 1538-4101 |
e-ISSN: | 1551-4005 |
Versão da editora: | https://www.tandfonline.com/doi/full/10.4161/15384101.2014.972868 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Patterning in time and space HoxB cluster gene expression in the developing chick embryo.pdf | 1,92 MB | Adobe PDF | Ver/Abrir |