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TitleMorphometry of corpus callosum in Williams syndrome: shape as an index of neural development
Author(s)Sampaio, Adriana
Bouix, Sylvain
Sousa, Nuno
Vasconcelos, Cristiana
Férnandez, Montse
Shenton, Martha E.
Gonçalves, Óscar F.
Case-Control Studies
Cognition Disorders
Corpus Callosum
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Models, Neurological
Neural Pathways
Neuropsychological Tests
Statistics as Topic
Williams Syndrome
Young Adult
Brain Mapping
Issue dateMay-2013
PublisherSpringer Heidelberg
JournalBrain Structure & Function
CitationSampaio, A., Bouix, S., Sousa, N., Vasconcelos, C., Férnandez, M., Shenton, M. E., & Gonçalves, O. F. (2013). Morphometry of corpus callosum in Williams syndrome: shape as an index of neural development. Brain Structure and Function, 218(3), 711-720.
Abstract(s)Brain abnormalities in Williams syndrome (WS) have been consistently reported, despite few studies have devoted attention to connectivity between different brain regions in WS. In this study, we evaluated corpus callosum (CC) morphometry: bending angle, length, thickness and curvature of CC using a new shape analysis method in a group of 17 individuals with WS matched with a typically developing group. We used this multimethod approach because we hypothesized that neurodevelopmental abnormalities might result in both volume changes and structure deformation. Overall, we found reduced absolute CC cross-sectional area and volume in WS (mean CC and subsections). In parallel, we observed group differences regarding CC shape and thickness. Specifically, CC of WS is morphologically different, characterized by a larger bending angle and being more curved in the posterior part. Moreover, although CC in WS is shorter, a larger relative thickness of CC was found in all callosal sections. Finally, groups differed regarding the association between CC measures, age, white matter volume and cognitive performance. In conclusions, abnormal patterns of CC morphology and shape may be implicated in WS cognitive and behavioural phenotype.
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AccessRestricted access (UMinho)
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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