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https://hdl.handle.net/1822/62079
Título: | Tips on how to collect and administer the mesenchymal stem cell secretome for central nervous system applications |
Autor(es): | Teixeira, F. G. Serra, S. C. Salgado, A. J. |
Palavras-chave: | Animals Cell Differentiation Cell Proliferation Cell Survival Central Nervous System Culture Media, Conditioned Humans Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells Proteome Proteomics Rats Regenerative Medicine Conditioned media Secretome Central nervous system In vivo |
Data: | 2016 |
Editora: | Humana Press |
Revista: | Methods in Molecular Biology |
Resumo(s): | Human mesenchymal stem cells (hMSCs) have been proposed as possible therapeutic agents for central nervous system (CNS) disorders. Recently, it has been suggested that their effects are mostly mediated through their secretome, which contains a number of neuroregulatory molecules capable of increasing cell proliferation, differentiation, and survival in different physiological conditions. Here, we present an overview of the hMSC secretome as a possible candidate in the creation of new cell-free therapies, demonstrating the process of its collection and route of administration, focusing our attention on their effects in CNS regenerative medicine. |
Tipo: | Capítulo de livro |
URI: | https://hdl.handle.net/1822/62079 |
ISBN: | 978-1-49-393582-6 |
DOI: | 10.1007/978-1-4939-3584-0_27 |
ISSN: | 1064-3745 |
e-ISSN: | 1940-6029 |
Acesso: | Acesso restrito autor |
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Ficheiro | Descrição | Tamanho | Formato | |
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teixeira2016.pdf Acesso restrito! | 216,96 kB | Adobe PDF | Ver/Abrir |