Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62011
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Campo DC | Valor | Idioma |
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dc.contributor.author | Leroy, Felix | por |
dc.contributor.author | Brann, David H. | por |
dc.contributor.author | Meira, Torcato Duarte Novo | por |
dc.contributor.author | Siegelbaum, Steven A. | por |
dc.date.accessioned | 2019-11-11T11:37:09Z | - |
dc.date.issued | 2017-08-30 | - |
dc.identifier.citation | Leroy, F., Brann, D. H., Meira, T., & Siegelbaum, S. A. (2017, August). Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron. Elsevier BV. http://doi.org/10.1016/j.neuron.2017.07.036 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | https://hdl.handle.net/1822/62011 | - |
dc.description.abstract | Input-timing-dependent plasticity (ITDP) is a circuit-based synaptic learning rule by which paired activation of entorhinal cortical (EC) and Schaffer collateral (SC) inputs to hippocampal CA1 pyramidal neurons (PNs) produces a long-term enhancement of SC excitation. We now find that paired stimulation of EC and SC inputs also induces ITDP of SC excitation of CA2 PNs. However, whereas CA1 ITDP results from long-term depression of feedforward inhibition (iLTD) as a result of activation of CB1 endocannabinoid receptors on cholecystokinin-expressing interneurons, CA2 ITDP results from iLTD through activation of δ-opioid receptors on parvalbumin-expressing interneurons. Furthermore, whereas CA1 ITDP has been previously linked to enhanced specificity of contextual memory, we find that CA2 ITDP is associated with enhanced social memory. Thus, ITDP may provide a general synaptic learning rule for distinct forms of hippocampal-dependent memory mediated by distinct hippocampal regions. | por |
dc.description.sponsorship | The authors thank Matt Bailey and Eleanor Simpson for their advice with the micro-perfusion system as well as Jung Park for his help preparing the videos. We are also grateful to Thomas Reardon for providing us with the N2C rabies virus and associated glycoprotein expressing rAAV. This work was supported by R01-MH104602 and R01-MH106629 from NIH (S.A.S.) and by PD/BD/113700/2015 from the Portuguese Foundation for Science and Technology (T.M.). | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | restrictedAccess | por |
dc.subject | Animals | por |
dc.subject | CA2 Region, Hippocampal | por |
dc.subject | Entorhinal Cortex | por |
dc.subject | Interneurons | por |
dc.subject | Long-Term Synaptic Depression | por |
dc.subject | Male | por |
dc.subject | Memory | por |
dc.subject | Mice | por |
dc.subject | Mice, Transgenic | por |
dc.subject | Neural Inhibition | por |
dc.subject | Neuronal Plasticity | por |
dc.subject | Parvalbumins | por |
dc.subject | Pyramidal Cells | por |
dc.subject | Receptors, Opioid, delta | por |
dc.subject | Social Behavior | por |
dc.subject | Time Factors | por |
dc.subject | CA2 | por |
dc.subject | delta opioid receptor | por |
dc.subject | ITDP | por |
dc.subject | social memory | por |
dc.title | Input-timing-dependent plasticity in the hippocampal CA2 region and its potential role in social memory | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationStartPage | 1089 | por |
oaire.citationEndPage | 1102 | por |
oaire.citationIssue | 5 | por |
oaire.citationVolume | 95 | por |
dc.identifier.eissn | 1097-4199 | - |
dc.identifier.doi | 10.1016/j.neuron.2017.07.036 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 28823730 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Neuron | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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10.1016_j.neuron.2017.07.036.pdf Acesso restrito! | 7,73 MB | Adobe PDF | Ver/Abrir |