Please use this identifier to cite or link to this item:

TitleAnatomical region differences and age-related changes in copper, zinc, and manganese levels in the human brain
Author(s)Ramos, Patrícia
Santos, Agostinho
Pinto, Nair Rosas
Mendes, Ricardo
Magalhães, Teresa
Almeida, Agostinho
Aged, 80 and over
Brain Chemistry
Middle Aged
Human brain
Postmortem analysis
Inductively coupled plasma-mass spectrometry
Issue dateNov-2014
JournalBiological Trace Element Research
CitationRamos, P., Santos, A., Pinto, N. R., Mendes, R., Magalhães, T., & Almeida, A. (2014). Anatomical region differences and age-related changes in copper, zinc, and manganese levels in the human brain. Biological trace element research, 161(2), 190-201.
Abstract(s)Using inductively coupled plasma-mass spectrometry after samples microwave-assisted acid digestion, zinc (Zn), copper (Cu), and manganese (Mn) levels were measured in 14 different areas of the human brain of adult individuals (n = 42; 71 ± 12, range 50-101 years old) without a known history of neurodegenerative, neurological, or psychiatric disorder. The main goals of the work were to establish the "normal" (reference) values for those elements in the human brain and to evaluate the age-related changes, a prior and indispensable step in order to enlighten the role of trace element (TE) in human brain physiology and their involvement in aging and neurodegenerative processes. Considering the mean values for the 14 regions, Zn (mean ± sd; range 53 ± 5; 43-61 μg/g) was found at higher levels, followed by Cu (22 ± 5; 10-37 μg/g) and Mn (1.3 ± 0.3; 0.5-2.7 μg/g). The TE distribution across the brain tissue showed to be quite heterogeneous: the highest levels of Zn were found in the hippocampus (70 ± 10; 49-95 μg/g) and superior temporal gyrus (68 ± 10; 44-88 μg/g) and the lowest in the pons (33 ± 8; 19-51 μg/g); the highest levels of Cu and Mn were found in the putamen (36 ± 13; 21-76 μg/g and 2.5 ± 0.8; 0.7-4.5 μg/g, respectively) and the lowest in the medulla (11 ± 6; 2-30 μg/g and 0.8 ± 0.3; 0.2-1.8 μg/g, respectively). A tendency for an age-related increase in Zn and Mn levels was observed in most brain regions while Cu levels showed to be negatively correlated with age.
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

Files in This Item:
File Description SizeFormat 
  Restricted access
1,28 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID