Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/61458
Título: | The stressed prefrontal cortex. Left? Right! |
Autor(es): | Cerqueira, João José Almeida, Osborne F. X. Sousa, Nuno |
Palavras-chave: | Adaptation, Psychological Animals Functional Laterality Humans Hypothalamo-Hypophyseal System Neurosecretory Systems Paraventricular Hypothalamic Nucleus Pituitary-Adrenal System Prefrontal Cortex Stress, Psychological HPA axis Hippocampus Handedness Hemispheric asymmetry Lateralization Immune response Autonomic nervous system stress |
Data: | Jul-2008 |
Editora: | Elsevier 1 |
Revista: | Brain, Behavior, and Immunity |
Resumo(s): | The prefrontal cortex (PFC) plays an important role in the integration of cognitive and affective behavior and regulating autonomic and neuroendocrine functions. This region of the brain, which may be considered analogous to the RAM memory of a computer, is important for translating stressful experience into adaptive behavior. The PFC responds to stress and modulates the response to stress through regulation of the hypothalamic paraventricular nucleus (PVN) which, in turn, controls sympathoadrenal and hypothalamic-pituitary-adrenal (HPA) activity. Interestingly, the latter convey the signals that link the CNS with the immune system. The present review highlights findings that contribute to elucidate the involvement of the PFC in the control of behavioral and neuroendocrine responses to chronic stress. It also considers the implications of these regulatory links for disorders of the nervous and immune systems. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/61458 |
DOI: | 10.1016/j.bbi.2008.01.005 |
ISSN: | 0889-1591 |
e-ISSN: | 1090-2139 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Cerqueira-2008-The-stressed-prefrontal-cortex-left.pdf | 594,12 kB | Adobe PDF | Ver/Abrir |