Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/61425
Título: | Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ulcerans infection |
Autor(es): | Fraga, Alexandra G. Branquinho, Gabriela Alexandra Trigo Murthy, Ramya K. Akhtar, Shamim Hebbur, Madhavi Pacheco, Ana Rita Dominguez, Juan Silva-Gomes, Rita Gonçalves, Carine M. Oliveira, Hugo Alexandre Mendes Castro, António G. Sharma, Umender Azeredo, Joana Pedrosa, Jorge |
Data: | 19-Ago-2019 |
Editora: | Public Library of Science |
Revista: | PLoS Neglected Tropical Diseases |
Citação: | Fraga, Alexandra G.; Branquinho, Gabriela Alexandra Trigo; Murthy, Ramya K.; Akhtar, Shamim; Hebbur, Madhavi; Pacheco, Ana Rita; Dominguez, Juan; Silva-Gomes, Rita; Gonçalves, Carine M.; Oliveira, Hugo; Castro, António G.; Sharma, Umender; Azeredo, Joana; Pedrosa, Jorge, Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ulcerans infection. PLoS Neglected Tropical Diseases, 13(8), 1-17, 2019 |
Resumo(s): | Buruli Ulcer (BU) is a necrotizing skin disease caused by Mycobacterium ulcerans. Although the current antibiotic treatment for BU is effective, daily administrations for a prolonged period of time, combined with potential risk of severe side effects, negatively impact on patient adherence. In that sense, we tested the efficacy of an alternative strategy based on Lysin B (LysB), a phage encoded lipolytic enzyme that degrades the mycolylarabinogalactan-peptidoglycan complex present in the mycobacterial cell wall. In this study, we show that LysB not only displays lytic activity against M. ulcerans isolates in vitro, but also leads to a decrease of M. ulcerans proliferation in infected mouse footpads. These findings highlight the potential use of lysins as a novel therapeutic approach against this neglected tropical disease. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/61425 |
DOI: | 10.1371/journal.pntd.0007113 |
ISSN: | 1935-2727 |
e-ISSN: | 1935-2735 |
Versão da editora: | http://journals.plos.org/plosntds/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_51960_1.pdf | 1,41 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons