Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/60932
Título: | Mesenchymal stem cells-derived exosomes: A new possible therapeutic strategy for Parkinson’s disease? |
Autor(es): | Vilaça-Faria, Helena Salgado, A. J. Teixeira, Fábio Gabriel Rodrigues |
Palavras-chave: | mesenchymal stem cells secretome exosomes Parkinson's disease microRNAs |
Data: | 2-Fev-2019 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | Cells |
Resumo(s): | Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide. Clinically, it is characterized by severe motor complications caused by a progressive degeneration of dopaminergic neurons (DAn) and dopamine loss. Current treatment is focused on mitigating the symptoms through administration of levodopa, rather than on preventing DAn damage. Therefore, the use and development of neuroprotective/disease-modifying strategies is an absolute need, which can lead to promising gains on PD translational research. Mesenchymal stem cells (MSCs)–derived exosomes have been proposed as a promising therapeutic tool, since it has been demonstrated that they can act as biological nanoparticles with beneficial effects in different pathological conditions, including PD. Thus, considering their potential protective action in lesioned sites, MSCs-derived exosomes might also be active modulators of the neuroregeneration processes, opening a door for their future use as therapeutical strategies in human clinical trials. Therefore, in this review, we analyze the current understanding of MSCs-derived exosomes as a new possible therapeutic strategy for PD, by providing an overview about the potential role of miRNAs in the cellular and molecular basis of PD. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/60932 |
DOI: | 10.3390/cells8020118 |
ISSN: | 2073-4409 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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cells-08-00118-v2.pdf | 1,49 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons