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https://hdl.handle.net/1822/59538
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Campo DC | Valor | Idioma |
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dc.contributor.author | Freitas, Ana Sofia | por |
dc.contributor.author | Cunha, Ana | por |
dc.contributor.author | Cardoso, Susana M. | por |
dc.contributor.author | Oliveira, Rui Pedro Soares de | por |
dc.contributor.author | Almeida Aguiar, Cristina | por |
dc.date.accessioned | 2019-03-18T10:45:47Z | - |
dc.date.issued | 2019-05 | - |
dc.identifier.citation | Freitas, Ana Sofia; Cunha, Ana; Cardoso, Susana M.; Oliveira, Rui; Aguiar, Cristina, Constancy of the bioactivities of propolis samples collected on the same apiary over four years. Food Research International, 119, 622-633, 2019 | por |
dc.identifier.issn | 0963-9969 | por |
dc.identifier.uri | https://hdl.handle.net/1822/59538 | - |
dc.description.abstract | Natural products, like propolis, have been subject of interest by several industries mainly due to their biological activities. However, besides being produced in low amounts propolis has a great variability in terms of chemical composition and bioactivities' profiles, constituting a problem for the development of propolis-based products and for its acceptance by the medical community. The aim of this work relates to the study of the bioactivities, in particular the antioxidant and the antimicrobial properties, as well as the chemical characterization of Portuguese propolis samples collected in an apiary sited at Gerês (G) along four consecutive years. Ethanol extracts of the four propolis samples (G.EEs) display antimicrobial activity, especially against Gram-positive spore forming bacteria. Antioxidant activity, evaluated by three different in vitro assays, was confirmed in vivo by flow cytometry using Saccharomyces cerevisiae as eukaryotic cell model. Cells incubated with G.EEs prior to H2O2 incubation, or incubated with G.EEs and H2O2 simultaneously, display higher viability than cells incubated only with H2O2, suggesting that G.EEs protect yeast cells against induced oxidative stress. All tested propolis samples exhibit very similar antimicrobial and antioxidant activities. Chemical analysis of G.EEs revealed no significant differences in terms of phenolic profiles, namely in the compounds to which propolis bioactivities are ascribed, thus supporting the more constant behavior evidenced by these propolis samples. This work highlights the valuable properties of this bee product and reveals a constancy of bioactivities in a Portuguese propolis sample over four years, raising awareness to the potentialities of this natural product often regarded as a beekeeping waste. | por |
dc.description.sponsorship | ThisworkwassupportedbyEuropeanInvestmentFundsbyFEDER/ COMPETE/POCI–Operacional Competitiveness and Internacionalization Programme, under Project POCI-01-0145-FEDER-006958 and National Funds by FCT - Portuguese Foundation for Science and Technology, under the project UID/AGR/04033/2013; FCT, the European Union, QREN, FEDER, COMPETE, through funding the Organic Chemistry Research Unit (QOPNA) (FCT UID/QUI/00062/2013), through national funds and where applicable co-financed by the FEDER, within the PT2020 Partnership Agreement. Susana Cardoso thanks the research contract under the project AgroForWealth (CENTRO-01-0145-FEDER 000001), funded by Centro 2020, through FEDER and PT2020. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147341/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147415/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | Propolis | por |
dc.subject | Antimicrobial | por |
dc.subject | Antioxidant | por |
dc.subject | Free radicals | por |
dc.subject | Phenolic compounds | por |
dc.subject | Chemical constancy | por |
dc.title | Constancy of the bioactivities of propolis samples collected on the same apiary over four years | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.journals.elsevier.com/food-research-international/ | por |
dc.comments | CEB48987 | por |
oaire.citationStartPage | 622 | por |
oaire.citationEndPage | 633 | por |
oaire.citationConferencePlace | Netherlands | - |
oaire.citationVolume | 119 | por |
dc.date.updated | 2019-03-17T17:42:45Z | - |
dc.identifier.doi | 10.1016/j.foodres.2018.10.040 | por |
dc.identifier.pmid | 30884697 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Food Research International | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series CBMA - Artigos/Papers DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_48987_1.pdf Acesso restrito! | 2,15 MB | Adobe PDF | Ver/Abrir |