Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58782
Título: | Metabolic regulation of innate immunity to fungal infection |
Autor(es): | Rodrigues, Cláudia S. Campos, Cláudia F. Cunha, Cristina Carvalho, Agostinho |
Palavras-chave: | Epigenetics Fungal disease Immunometabolism Trained immunity β-glucan |
Data: | 2018 |
Revista: | Experientia Supplementum |
Resumo(s): | In recent years, the renewed interest in immune cell metabolism has driven the emergence of a research field aimed at studying the role of metabolic processes during innate and adaptive immune responses. Although the specific requirements of myeloid cells after the canonical lipopolysaccharide/TLR4 stimulation have been extensively addressed, recent evidence suggests that this model may not represent a universally accurate metabolic blueprint. Instead, different microbial stimuli, pathogens, or tissue microenvironments trigger specific and complex metabolic rewiring of myeloid cells. This chapter aims to provide an overview of the metabolic heterogeneity in activated myeloid cells during fungal disease. Directions for future research in dissecting the uniqueness of metabolic signatures during fungal infection are suggested to ultimately provide new tailored diagnostic and therapeutic interventions. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/58782 |
DOI: | 10.1007/978-3-319-74932-7_11 |
ISSN: | 1664-431X |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Metabolic regulation of innate immunity to fungal infection.pdf Acesso restrito! | 469,4 kB | Adobe PDF | Ver/Abrir |