Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/58778

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dc.contributor.authorMesquita, Inês Moraispor
dc.contributor.authorRodrigues, Fernando José dos Santospor
dc.date.accessioned2019-01-30T15:19:59Z-
dc.date.issued2018-
dc.identifier.issn1664-431Xpor
dc.identifier.urihttps://hdl.handle.net/1822/58778-
dc.description.abstractMetabolism is highly coordinated component of the cellular activity that involves sequential chemical transformations, within a so-called metabolic network. Through these coordinated actions, living organisms acquire energy and biosynthetic precursors to maintain cellular homeostasis and function. Metabolism relies on the breaking down of macromolecules to produce energy [catabolism] and/or intermediary metabolites that are then used to construct essential building blocks for macromolecule production [anabolism]. Overall, these metabolic processes are controlled by cellular energy status: when the energy released from catabolic processes exceeds the cellular demands the storage of metabolites in the form of lipids and glycogen takes place. These phenomena have been vastly associated with the genesis of metabolic disorders, such as obesity. In recent years, we have assisted to a rediscovery of metabolism through the identification of metabolic intermediaries that act as key players on differentiation, proliferation, and function of immune cells. This recent acknowledgement of the impact of metabolism in the overall immune response originated the ground-breaking field of immunometabolism. Here, we will provide a holistic view of metabolism highlighting the biochemical principles underlying its regulation.por
dc.description.sponsorship(undefined)por
dc.language.isoengpor
dc.rightsclosedAccesspor
dc.subjectBiosynthetic precursorspor
dc.subjectEnergypor
dc.subjectHomeostasispor
dc.subjectImmunometabolismpor
dc.subjectMetabolic networkspor
dc.subjectMetabolic nodespor
dc.subjectRegulationpor
dc.titleCellular metabolism at a glancepor
dc.typearticlepor
oaire.citationStartPage3por
oaire.citationEndPage27por
oaire.citationVolume109-
dc.identifier.doi10.1007/978-3-319-74932-7_1por
dc.identifier.pmid30535597por
dc.description.publicationversioninfo:eu-repo/semantics/publishedVersionpor
sdum.journalExperientia Supplementumpor
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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