Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58258
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Santos, K. M. | por |
dc.contributor.author | Gomes, I. N. F. | por |
dc.contributor.author | Silva-Oliveira, R. J. | por |
dc.contributor.author | Pinto, F. E. | por |
dc.contributor.author | Oliveira, B. G. | por |
dc.contributor.author | Chagas, R. C. R. | por |
dc.contributor.author | Romão, W. | por |
dc.contributor.author | Reis, R. M. | por |
dc.contributor.author | Ribeiro, R. I. M. A. | por |
dc.date.accessioned | 2019-01-16T10:16:58Z | - |
dc.date.available | 2019-01-16T10:16:58Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Santos, K. M., Gomes, I. N. F., Silva-Oliveira, R. J., Pinto, F. E., Oliveira, B. G., Chagas, R. C. R., ... & Ribeiro, R. I. M. A. (2018). Bauhinia variegata candida Fraction Induces Tumor Cell Death by Activation of Caspase-3, RIP, and TNF-R1 and Inhibits Cell Migration and Invasion In Vitro. BioMed research international, 2018 | por |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | https://hdl.handle.net/1822/58258 | - |
dc.description.abstract | Metastasis remains the most common cause of death in cancer patients. Inhibition of metalloproteinases (MMPs) is an interesting approach to cancer therapy because of their role in the degradation of extracellular matrix (ECM), cell-cell, and cell-ECM interactions, modulating key events in cell migration and invasion. Herein, we show the cytotoxic and antimetastatic effects of the third fraction (FR3) from Bauhinia variegata candida (Bvc) stem on human cervical tumor cells (HeLa) and human peripheral blood mononuclear cells (PBMCs). FR3 inhibited MMP-2 and MMP-9 activity, indicated by zymogram. This fraction was cytotoxic to HeLa cells and noncytotoxic to PBMCs and decreased HeLa cell migration and invasion. FR3 is believed to stimulate extrinsic apoptosis together with necroptosis, assessed by western blotting. FR3 inhibited MMP-2 activity in the HeLa supernatant, differently from the control. The atomic mass spectrometry (ESI-MS) characterization suggested the presence of glucopyranosides, D-pinitol, fatty acids, and phenolic acid. These findings provide insight suggesting that FR3 contains components with potential tumor-selective cytotoxic action in addition to the action on the migration of tumor cells, which may be due to inhibition of MMPs. | por |
dc.description.sponsorship | Fundação de Amparo à Pesquisa de Minas Gerais (FAPEMIG), Fundação CAPES, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ), and FINEP (MCTI/FINEP/MS/SCTIE/DECIT-01/2013-FPXII-BIOPLAT) | por |
dc.language.iso | eng | por |
dc.publisher | Hindawi Publishing Corporation | por |
dc.rights | openAccess | por |
dc.subject | Apoptosis | por |
dc.subject | Bauhinia | por |
dc.subject | Caspase 3 | por |
dc.subject | Cell Death | por |
dc.subject | Cell Line, Tumor | por |
dc.subject | Cell Movement | por |
dc.subject | Cytotoxins | por |
dc.subject | Fatty Acids | por |
dc.subject | HeLa Cells | por |
dc.subject | Humans | por |
dc.subject | Hydroxybenzoates | por |
dc.subject | Inositol | por |
dc.subject | Leukocytes, Mononuclear | por |
dc.subject | Matrix Metalloproteinase 2 | por |
dc.subject | Matrix Metalloproteinase 9 | por |
dc.subject | Neoplasm Invasiveness | por |
dc.subject | Plant Extracts | por |
dc.subject | Receptor-Interacting Protein Serine-Threonine Kinases | por |
dc.subject | Receptors, Tumor Necrosis Factor, Type I | por |
dc.subject | Signal Transduction | por |
dc.title | Bauhinia variegata candida Fraction Induces Tumor Cell Death by Activation of Caspase-3, RIP, and TNF-R1 and Inhibits Cell Migration and Invasion In Vitro | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.hindawi.com/journals/bmri/2018/4702481/abs/ | por |
oaire.citationIssue | 4702481 | por |
oaire.citationVolume | 2018 | por |
dc.identifier.eissn | 2314-6141 | - |
dc.identifier.doi | 10.1155/2018/4702481 | por |
dc.identifier.pmid | 29770331 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Biomed Research International | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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santos 2018.pdf | 3,41 MB | Adobe PDF | Ver/Abrir |