Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58130
Título: | Absence of TERT promoter mutations in colorectal precursor lesions and cancer |
Autor(es): | Cruvinel-Carloni, Adriana Yamane, Letícia Scapulatempo-Neto, Cristovam Guimarães, Denise Reis, R. M. |
Palavras-chave: | Colorectal carcinoma TERT promoter mutations Precursor lesions |
Data: | 2018 |
Editora: | Sociedade Brasileira de Genética |
Revista: | Genetics and Molecular Biology |
Citação: | Cruvinel-Carloni, A., Yamane, L., Scapulatempo-Neto, C., Guimarães, D., & Reis, R. M. (2018). Absence of TERT promoter mutations in colorectal precursor lesions and cancer. Genetics and molecular biology, 41(1), 82-84 |
Resumo(s): | Hotspot mutations (c.-124bp G > A and c.-146bp G > A) in the promoter region of the TERT gene have been recently described in several types of solid tumors, including glioma, bladder, thyroid, liver and skin neoplasms. However, knowledge with respect to colorectal precursor lesions and cancer is scarce. In the present study we aimed to determine the frequency of hotspot TERT promoter mutations in 145 Brazilian patients, including 103 subjects with precursor lesions and 42 with colorectal carcinomas, and we associated the presence of such mutations with the patients clinical-pathological features. The mutation analysis was conclusive in 123 cases, and none of the precursor and colorectal carcinoma cases showed TERT promoter mutations. We conclude that TERT mutations are not a driving factor in colorectal carcinogenesis. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/58130 |
DOI: | 10.1590/1678-4685-GMB-2017-0133 |
ISSN: | 1415-4757 |
e-ISSN: | 1678-4685 |
Versão da editora: | http://www.scielo.br/scielo.php?pid=S1415-47572018000100082&script=sci_arttext |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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cruvinel-carloni2018.pdf | 310,7 kB | Adobe PDF | Ver/Abrir |