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https://hdl.handle.net/1822/57931| Título: | A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97 |
| Autor(es): | Ramalho-Carvalho, João Gonçalves, Celine Saraiva Graça, Inês Bidarra, David Pereira-Silva, Eva Salta, Sofia Godinho, Maria Inês Gomez, Antonio Esteller, Manel Costa, Bruno Marques Henrique, Rui Jerónimo, Carmen |
| Palavras-chave: | miR-152-3p Prostate cancer Cell cycle DNA methylation CRISPR TMEM97 |
| Data: | 2018 |
| Editora: | Springer Nature |
| Revista: | Clinical Epigenetics |
| Citação: | Ramalho-Carvalho, J., Gonçalves, C. S., Graça, I., Bidarra, D., Pereira-Silva, E., Salta, S., ... & Henrique, R. (2018). A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97. Clinical epigenetics, 10(1), 40 |
| Resumo(s): | Prostate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. MicroRNAs are globally downregulated in PCa, especially in poorly differentiated tumors. Nonetheless, the underlying mechanisms are still elusive. Herein, using combined analysis of microRNAs expression and genomewide DNA methylation, we aimed to identify epigenetically downregulated microRNAs in PCa. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/57931 |
| DOI: | 10.1186/s13148-018-0475-2 |
| ISSN: | 1868-7075 |
| e-ISSN: | 1868-7083 |
| Versão da editora: | https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-018-0475-2 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| RAMALH~1.PDF | 2,65 MB | Adobe PDF | Ver/Abrir |
