Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/57920
Título: | A Key Role for Neurotensin in Chronic-Stress-Induced Anxiety-Like Behavior in Rats |
Autor(es): | Normandeau, Catherine P. Silva, Ana Paula Ventura Hawken, Emily R. Angelis, Staci Sjaarda, Calvin Liu, Xudong Pêgo, José M. Dumont, É. C. |
Palavras-chave: | Animals Behavior, Animal Chronic Disease Corticotropin-Releasing Hormone Disease Models, Animal Neural Inhibition Neurons Neurotensin Rats Rats, Long-Evans Rats, Wistar Receptors, Neurotensin Synaptic Transmission Anxiety Septal Nuclei Stress, Psychological |
Data: | Jan-2018 |
Editora: | Springer Nature |
Revista: | Neuropsychopharmacology |
Citação: | Normandeau, C. P., Ventura-Silva, A. P., Hawken, E. R., Angelis, S., et. al.(2018). A key role for neurotensin in chronic-stress-induced anxiety-like behavior in rats. Neuropsychopharmacology, 43(2), 285 |
Resumo(s): | Chronic stress is a major cause of anxiety disorders that can be reliably modeled preclinically, providing insight into alternative therapeutic targets for this mental health illness. Neuropeptides have been targeted in the past to no avail possibly due to our lack of understanding of their role in pathological models. In this study we use a rat model of chronic stress-induced anxiety-like behaviors and hypothesized that neuropeptidergic modulation of synaptic transmission would be altered in the bed nucleus of the stria terminalis (BNST), a brain region suspected to contribute to anxiety disorders. We use brain slice neurophysiology and behavioral pharmacology to compare the role of locally released endogenous neuropeptides on synaptic transmission in the oval (ov) BNST of non-stressed (NS) or chronic unpredictably stressed (CUS) rats. We found that in NS rats, post-synaptic depolarization induced the release of vesicular neurotensin (NT) and corticotropin-releasing factor (CRF) that co-acted to increase ovBNST inhibitory synaptic transmission in 59% of recorded neurons. CUS bolstered this potentiation (100% of recorded neurons) through an enhanced contribution of NT over CRF. In contrast, locally released opioid neuropeptides decreased ovBNST excitatory synaptic transmission in all recorded neurons, regardless of stress. Consistent with CUS-induced enhanced modulatory effects of NT, blockade of ovBNST NT receptors completely abolished stress-induced anxiety-like behaviors in the elevated plus maze paradigm. The role of NT has been largely unexplored in stress and our findings highlight its potential contribution to an important behavioral consequence of chronic stress, that is, exaggerated avoidance of open space in rats. |
Tipo: | Artigo |
Descrição: | Accepted Manuscript |
URI: | https://hdl.handle.net/1822/57920 |
DOI: | 10.1038/npp.2017.134 |
ISSN: | 1740-634X |
Versão da editora: | https://www.nature.com/articles/npp2017134 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
normandeau2017.pdf | 10,95 MB | Adobe PDF | Ver/Abrir |