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https://hdl.handle.net/1822/56517
Título: | Genomic analysis of Acinetobacter baumannii prophages reveals remarkable diversity and suggests profound impact on bacterial virulence and fitness |
Autor(es): | Costa, Ana Rita Monteiro, Rodrigo Azeredo, Joana |
Data: | 2018 |
Editora: | Nature Group |
Revista: | Scientific Reports |
Citação: | Costa, Ana Rita; Monteiro, Rodrigo; Azeredo, Joana, Genomic analysis of Acinetobacter baumannii prophages reveals remarkable diversity and suggests profound impact on bacterial virulence and fitness. Scientific Reports, 8(15346), 2018. doi 10.1038/s41598-018-33800-5 |
Resumo(s): | The recent nomination by the World Health Organization of Acinetobacter baumannii as the number one priority pathogen for the development of new antibiotics is a direct consequence of its fast evolution of pathogenicity, and in particular of multidrug resistance. While the development of new antibiotics is critical, understanding the mechanisms behind the crescent bacterial antibiotic resistance is equally relevant. Often, resistance and other bacterial virulence elements are contained on highly mobile pieces of DNA that can easily spread to other bacteria. Prophages are one of the mediators of this form of gene transfer, and have been frequently found in bacterial genomes, often offering advantageous features to the host. Here we assess the contribution of prophages for the evolution of A. baumannii pathogenicity. We found prophages to be notably diverse and widely disseminated in A. baumannii genomes. Also remarkably, A. baumannii prophages encode for multiple putative virulence factors that may be implicated in the bacteriums capacity to colonize host niches, evade the host immune system, subsist in unfavorable environments, and tolerate antibiotics. Overall our results point towards a significant contribution of prophages for the dissemination and evolution of pathogenicity in A. baumannii, and highlight their clinical relevance. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/56517 |
DOI: | 10.1038/s41598-018-33800-5 |
ISSN: | 2045-2322 |
e-ISSN: | 2045-2322 |
Versão da editora: | http://www.nature.com/srep/index.html |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_49011_1.pdf | 15,47 MB | Adobe PDF | Ver/Abrir |