Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/55933
Título: | Lipid nanocarriers loaded with natural compounds: Potential new therapies for age related neurodegenerative diseases? |
Autor(es): | Soares, Telma Bezerra Loureiro, Luís Carvalho, Ana Real Oliveira, M. Elisabete C.D. Dias, Alberto Carlos Pires Sarmento, Bruno Lúcio, Marlene |
Palavras-chave: | Lipid nanocarriers Natural compounds Blood brain barrier Neurooxidation Neuroinflammation Targeting Triggering |
Data: | 14-Set-2018 |
Editora: | Elsevier 1 |
Revista: | Progress in Neurobiology |
Citação: | Bezerra Soares, T., Progress in Neurobiology (2018), https://doi.org/10.1016/j.pneurobio.2018.04.004 |
Resumo(s): | Age related neurodegenerative disorders (ARND) are presented as the most debilitating and challenging diseases associated with the central nervous system. Despite the advent of active molecules with a positive role on neurodegenerative mechanisms, many of the current therapeutic strategies remain ineffective in treating or preventing ARND. Lipid nanocarriers have emerged as efficient delivery systems with the capability to cross biological barriers, especially the blood brain barrier (BBB). Also, when associated to natural compounds, lipid nanocarriers have demonstrated to be an interesting alternative to ARND therapies with multiple beneficial effects. This comprehensive review focus on state-of-the-art lipid based nanocarriers for the delivery of natural compounds targeting neurodegeneration. A critical analysis of published reports will be also provided giving indications to researchers about the most promising ARND nanotherapy strategies. |
Tipo: | Artigo |
Descrição: | Article in press |
URI: | https://hdl.handle.net/1822/55933 |
DOI: | 10.1016/j.pneurobio.2018.04.004 |
ISSN: | 0301-0082 |
e-ISSN: | 1873-5118 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S0301008218300066 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDF - FAMO - Artigos/Papers (with refereeing) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Telma Bezerra et al Prog Neur.2018.pdf | 2,61 MB | Adobe PDF | Ver/Abrir |