Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/51989
Título: | Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT- 15 cell lines |
Autor(es): | Noro, Jennifer Martins Maciel, J. Duarte, D. Olival, A. C. D. Baptista, C. Silva, A. C. D. Alves, Maria José Chão Kong, Thoo Lin |
Palavras-chave: | Toxicity Tetrabromide Naphthalimide Isocyanate Membrane permeabilization |
Data: | 2015 |
Editora: | OMICS International |
Revista: | Organic Chemistry: Current Research |
Citação: | Noro J, Maciel J, Duarte D, Olival ACD, Baptista C, et al. (2015) Evaluation of New Naphthalimides as Potential Anticancer Agents against Breast Cancer MCF-7, Pancreatic Cancer BxPC-3 and Colon Cancer HCT-15 Cell Lines. Organic Chem Curr Res 4: 144. doi:10.4172/21610401.1000144 |
Resumo(s): | New 1,8-naphthalimido derivatives with 2,3 and 4 carbon chains bearing a number of different functionalities were synthesized and tested against a panel of breast cancer MCF-7, colon cancer HCT-15 and pancreatic cancer BxPC-3 cell lines. Generally structures with shorter alkyl chains were more active, with the one exception of the amide containing a p-nitrophenyl group. GI50 values (µM) were determined for the most active compounds. Three compounds exhibited GI50 values below 5 µM, two with MCF-7 cells, and one other with HCT-15. Compounds with different functionalities demonstrated cell line specificity: the MCF-7 cell line was more sensitive to an urea derivative (6f), the growth of HCT15 cells were most affected by a triazole (9d), while the BxPC-3 cell line was inhibited in a higher extend by a guanidine (4a). |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/51989 |
DOI: | 10.4172/2161-0401.1000144 |
ISSN: | 2161-0401 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Organic Chemistry. current research.pdf Acesso restrito! | 985,2 kB | Adobe PDF | Ver/Abrir |