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Título: | Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium |
Autor(es): | Freschi, Luca Jeukens, Julie Kukavica-Ibrulj, Irene Boyle, Brian Dupont, Marie-Josee Laroche, Jerome Larose, Stephane Maaroufi, Halim Fothergill, Joanne L. Moore, Matthew Winsor, Geoffrey L. Aaron, Shawn D. Barbeau, Jean Bell, Scott C. Burns, Jane L. Camara, Miguel Cantin, Andre Charette, Steve J. Dewar, Ken Deziel, Eric Grimwood, Keith Hancock, Robert E. W. Harrison, Joe J. Heebs, Stephan Jelsbak, Lars Jia, Baofeng Kenna, Dervla T. Kidd, Timothy J. Klockgether, Jens Lam, Joseph S. Lamont, Iain L. Lewenza, Shawn Loman, Nick Malouin, Francois Manos, Jim McArthur, Andrew G. McKeown, Josie Milot, Julie Naghra, Hardeep Nguyen, Dao Pereira, Sheldon K. Perron, Gabriel G. Pirnay, Jean-Paul Rainey, Paul B. Rousseau, Simon Santos, P. M. Stephenson, Anne Taylor, Veronique Turton, Jane F. Waglechner, Nicholas Williams, Paul |
Palavras-chave: | Pseudomonas aeruginosa next-generation sequencing bacterial genome phylogeny database cystic fibrosis antibiotic resistance clinical microbiology |
Data: | 29-Set-2015 |
Editora: | Frontiers Media |
Revista: | Frontiers in Microbiology |
Resumo(s): | The International Pseudomonas aeruginosa Consortium is sequencing over 1000 genomes and building an analysis pipeline for the study of Pseudomonas genome evolution, antibiotic resistance and virulence genes. Metadata, including genomic and phenotypic data for each isolate of the collection, are available through the International Pseudomonas Consortium Database (http://ipcd.ibis.ulaval.ca/). Here, we present our strategy and the results that emerged from the analysis of the first 389 genomes. With as yet unmatched resolution, our results confirm that P. aerugihosa strains can be divided into three major groups that are further divided into subgroups, some not previously reported in the literature. We also provide the first snapshot of P aeruginosa strain diversity with respect to antibiotic resistance. Our approach will allow us to draw potential links between environmental strains and those implicated in human and animal infections, understand how patients become infected and how the infection evolves over time as well as identify prognostic markers for better evidence-based decisions on patient care. |
Tipo: | Artigo |
Descrição: | The Supplementary Material for this article can be found online at: http://journal.frontiersin.org/article/10.3389/fmicb. 2015.01036 |
URI: | https://hdl.handle.net/1822/51981 |
DOI: | 10.3389/fmicb.2015.01036 |
ISSN: | 1664-302X |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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fmicb-06-01036.pdf | 1,93 MB | Adobe PDF | Ver/Abrir |