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https://hdl.handle.net/1822/50210
Título: | Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors |
Autor(es): | Abrahão-Machado, Lucas Faria Antunes, Bruno Filippi, Renee Zon Volc, Sahlua Boldrini, Erica Menezes, Weder P. Reis, R. M. Camargo, Olavo Pires de |
Palavras-chave: | Biomarkers ESFT Ewing sarcoma family of tumors Methylthioadenosine phosphorylase MTAP Prognosis |
Data: | 2018 |
Editora: | Future Medicine Ltd |
Revista: | Biomarkers in Medicine |
Citação: | Abrahao-Machado, L. F., Antunes, B., Filippi, R. Z., Volc, S., et. al. (2018). Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors. Biomarkers in medicine, 12(1), 35-44 |
Resumo(s): | AIM: The Ewing sarcoma family of tumors (ESFT) is a group of malignant small round cell neoplasms of bones and soft tissues closely histogenetically related. Methylthioadenosine phosphorylase (MTAP) deficiency has been recently associated with increased tumor aggressiveness and poor outcomes in different types of neoplasms. However, the expression of this biomarker and its biological role in ESFT remain largely unknown. METHODS: Immunohistochemical expression of MTAP was accessed in 112 patients with ESFT in a tissue microarray platform and associated with clinicopathological parameters and overall survival(OS). RESULTS: Loss of MTAP expression was significantly associated with lower OS in both univariate and multivariate analyses. CONCLUSION: Loss of MTAP expression is an independent negative prognostic biomarker in ESFT. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/50210 |
DOI: | 10.2217/bmm-2017-0152 |
ISSN: | 1752-0363 |
e-ISSN: | 1752-0371 |
Versão da editora: | https://www.futuremedicine.com/doi/abs/10.2217/bmm-2017-0152 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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2018 abrahaomachadolf.pdf | 909,8 kB | Adobe PDF | Ver/Abrir |