Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/50174
Título: | Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function |
Autor(es): | Sardinha, Vanessa Alexandra Morais Gomes, Sónia Isabel Nunes Guerra Campos, Inês Caetano Costa Tavares, Gabriela Pires Martins, Manuella Mendes Reis, Joana Vanessa Santos Correia, Joana Sofia Silva Castro, Andreia Cristiana Teixeira Pinto, Luísa Sousa, Nuno Oliveira, João F. |
Palavras-chave: | astrocyte behavior local field potential neuronal morphology oscillations |
Data: | Dez-2017 |
Editora: | Wiley |
Revista: | Glia |
Resumo(s): | Astrocytes interact with neurons at the cellular level through modulation of synaptic formation, maturation, and function, but the impact of such interaction into behavior remains unclear. Here, we studied the dominant negative SNARE (dnSNARE) mouse model to dissect the role of astrocyte-derived signaling in corticolimbic circuits, with implications for cognitive processing. We found that the blockade of gliotransmitter release in astrocytes triggers a critical desynchronization of neural theta oscillations between dorsal hippocampus and prefrontal cortex. Moreover, we found a strong cognitive impairment in tasks depending on this network. Importantly, the supplementation with D-serine completely restores hippocampal-prefrontal theta synchronization and rescues the spatial memory and long-term memory of dnSNARE mice. We provide here novel evidence of long distance network modulation by astrocytes, with direct implications to cognitive function. |
Tipo: | Artigo |
Descrição: | Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function |
URI: | https://hdl.handle.net/1822/50174 |
DOI: | 10.1002/glia.23205 |
ISSN: | 0894-1491 |
e-ISSN: | 1098-1136 |
Versão da editora: | http://onlinelibrary.wiley.com/doi/10.1002/glia.23205/abstract |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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2017 sardinhavm.pdf | 2,3 MB | Adobe PDF | Ver/Abrir |