Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/49322
Título: | Photorelease of glycine and beta-alanine from (7-bromocoumarin-4-yl)methyl cages |
Autor(es): | Conceição, Rafaela C. O. Costa, Susana P. G. Gonçalves, M. Sameiro T. |
Palavras-chave: | Glycine Beta-alanine Photolysis Coumarin |
Data: | 2015 |
Editora: | MDPI |
Citação: | Proceedings of the 19th Int. Electron. Conf. Synth. Org. Chem., 1–30 November 2015; Sciforum Electronic Conference Series, Vol. 19, 2015, a015; doi:10.3390/ecsoc-19-a015. |
Resumo(s): | The synthesis of a new 7-bromo-4-(chloromethyl)-coumarin to be used as cage for the release of bioactive molecules is presented. Ester cages of two neurotransmitter amino acids, glycine and β-alanine, were also synthetized. These neurotransmitters were chosen as models due to their biological relevance. The glycine and β-alanine ester conjugates, in methanol/HEPES buffer (80:20), were irradiated at 254, 300, 350 and 419 nm in a Rayonet RPR-100 photochemical reactor and the photolysis process was followed by HPLC with UV detection. These results were compared with those previously obtained by our research group when 4-chloromethyl-coumarin was used in the photorelease of glycine and β-alanine. |
Tipo: | Artigo em ata de conferência |
URI: | https://hdl.handle.net/1822/49322 |
ISBN: | 978-3-03842-145-0 |
DOI: | 10.3390/ecsoc-19-a015 |
Versão da editora: | http://sciforum.net/conference/ecsoc-19/paper/3040 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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proceeding ECSOC Rafaela repositorium.pdf | 720,12 kB | Adobe PDF | Ver/Abrir |